M
M. Koenig
Researcher at Howard Hughes Medical Institute
Publications - 8
Citations - 3650
M. Koenig is an academic researcher from Howard Hughes Medical Institute. The author has contributed to research in topics: Duchenne muscular dystrophy & Dystrophin-associated protein complex. The author has an hindex of 7, co-authored 8 publications receiving 3576 citations. Previous affiliations of M. Koenig include Boston Children's Hospital.
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Journal ArticleDOI
The Complete Sequence of Dystrophin Predicts a Rod-Shaped Cytoskeletal Protein
M. Koenig,M. Koenig,Anthony P. Monaco,Anthony P. Monaco,Louis M. Kunkel,Louis M. Kunkel,Louis M. Kunkel +6 more
TL;DR: The complete sequence of the human Duchenne muscular dystrophy cDNA has been determined and dystrophin shares many features with the cytoskeletal protein spectrin and alpha-actinin and is likely to adopt a rod shape about 150 nm in length.
Journal Article
The molecular basis for duchenne versus becker muscular dystrophy: correlation of severity with type of deletion
M. Koenig,Alan H. Beggs,M. Moyer,S. Scherpf,K. Heindrich,T. Bettecken,G Meng,C. R. Müller,M. Lindlöf,H. Kaariainen,A. de la Chapelle,A. Kiuru,M.-L. Savontaus,H. Gilgenkrantz,D. Récan,J. Chelly,Jean-Claude Kaplan,A. E. Covone,N. Archidiacono,Giovanni Romeo,S. Liechti-Gallati,V. Schneider,Suzanne Braga,H. Moser,Basil T. Darras,Patricia E. Murphy,Uta Francke,J. D. Chen,Graeme Morgan,Margaret Denton,Cheryl R. Greenberg,Klaus Wrogemann,L. A. J. Blonden,H.M.B. van Paassen,G.J.B. van Ommen,Louis M. Kunkel +35 more
TL;DR: The distribution and frequency of deletions spanning the entire locus suggests that many "in-frame" deletions of the dystrophin gene are not detected because the individuals bearing them are either asymptomatic or exhibit non-DMD/non-BMD clinical features.
Journal ArticleDOI
Detection of 98% of DMD/BMD gene deletions by polymerase chain reaction
TL;DR: Using oligonucleotide primer sequences that can be used to amplify eight exons plus the muscle promoter of the dystrophin gene in a single multiplex polymerase chain reaction (PCR) will allow deletion detection and prenatal diagnosis for most DMD/BMD patients in a fraction of the time required for Southern blot analysis.
Journal ArticleDOI
Detailed analysis of the repeat domain of dystrophin reveals four potential hinge segments that may confer flexibility.
M. Koenig,Louis M. Kunkel +1 more
TL;DR: A model for a membrane-associated network of dystrophin in which the hinges play a key role by conferring flexibility to the network and thus resilience to the membrane is presented.
Journal Article
Localization of DNA sequences in region Xp21 of the human X chromosome: Search for molecular markers close to the duchenne muscular dystrophy locus
de Martinville B,Louis M. Kunkel,G. A. P. Bruns,F. Morle,M. Koenig,Jean-Louis Mandel,A. Horwich,Samuel A. Latt,James F. Gusella,D. Housman +9 more
TL;DR: The ornithine transcarbamylase gene and four anonymous DNA sequences map within band Xp21, flanking the presumed locus for Duchenne muscular dystrophy, as well as five different regions of the short arm of the X chromosome.