G Theilmeier

TL;DR: The recombinant lectin-like domain of TM suppresses PMN adhesion to ECs, diminishes cytokine-induced increase in nuclear factor κB and activation of ERK1/2, and rescues ECs from serum starvation, suggesting that TM has antiinflammatory properties in addition to its role in coagulation and fibrinolysis.

TL;DR: In patients with severe acute lung injury and multiple organ failure, inhaled prostaglandin E1 improved oxygenation and decreased venous admixture without affecting systemic hemodynamic variables.

TL;DR: The data suggest increased CO-generation in critical illness and pulmonary CO-production in healthy and critically ill humans.

TL;DR: It is demonstrated that porcine studies can further elucidate the role of OPRs in cardiac (patho-)physiology and modulation of cardiac function by δ- and κ-OPR agonists or antagonists is therefore possible, while μ-opR-mediated direct cardiac effects appear unlikely.