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Gabriela Kramer-Marek

Researcher at Institute of Cancer Research

Publications -  66
Citations -  2078

Gabriela Kramer-Marek is an academic researcher from Institute of Cancer Research. The author has contributed to research in topics: In vivo & Affibody molecule. The author has an hindex of 25, co-authored 57 publications receiving 1771 citations. Previous affiliations of Gabriela Kramer-Marek include National Institutes of Health & Indiana University – Purdue University Indianapolis.

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Diagnostic and Therapeutic Biomarkers in Glioblastoma: Current Status and Future Perspectives.

TL;DR: The exciting progress towards elucidating the potential of current and novel GBM biomarkers is reviewed and their implications for clinical practice are discussed.
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Affibody Molecules for In vivo Characterization of HER2-Positive Tumors by Near-Infrared Imaging

TL;DR: The results suggest that Affibody-Alexa Fluor conjugates may be used as a specific NIR probe for the noninvasive semiquantitative imaging of HER2 expression in vivo.
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[18F]FBEM-ZHER2:342-Affibody molecule - a new molecular tracer for in vivo monitoring of HER2 expression by positron emission tomography

TL;DR: The results suggest that the [18F]FBEM-ZHER2:342 radioconjugate can be used to assess HER2 expression in vivo and lowered the accumulation of radioactivity in HER2-positive tumors to the levels observed in Her2-negative ones.
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Changes in HER2 expression in breast cancer xenografts after therapy can be quantified using PET and (18)F-labeled affibody molecules.

TL;DR: The results suggest that the described 18F-FBEM–ZHER2:342 Affibody molecule can be used to assess HER2 expression in vivo by PET and monitor possible changes of receptor expression in response to therapeutic interventions.
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HER2-specific affibody-conjugated thermosensitive liposomes (Affisomes) for improved delivery of anticancer agents.

TL;DR: Thermosensitive liposomes present promising, novel drug-delivery candidates for breast cancer targeting as well as nontargeted SUV candidates, and Affisomes, when stored at room temperature, retained > 90% entrapped calcein up to 7 days.