R
Robert Blumenthal
Researcher at National Institutes of Health
Publications - 141
Citations - 10004
Robert Blumenthal is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Lipid bilayer fusion & Gp41. The author has an hindex of 53, co-authored 141 publications receiving 9603 citations. Previous affiliations of Robert Blumenthal include Baylor College of Medicine & University of Rochester.
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Design of liposomes for enhanced local release of drugs by hyperthermia
TL;DR: Liposomes can be designed to release an entrapped drug preferentially at temperatures attainable by mild local hyperthermia, suggesting possible applications in the treatment of tumors or local infection.
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Lipid-based Nanoparticles as Pharmaceutical Drug Carriers: From Concepts to Clinic
Anu Puri,Kristin H. Loomis,Brandon Smith,Jae-Ho Lee,Amichai Yavlovich,Eliahu Heldman,Robert Blumenthal +6 more
TL;DR: This review will primarily focus on the recent advances and updates on lipid-based nanoparticles for their projected applications in drug delivery, including a review of current activities in the field of liposomes, and challenging issues of targeting and triggering will be discussed in detail.
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Liposome-Cell Interaction: Transfer and Intracellular Release of a Trapped Fluorescent Marker
TL;DR: When small, unilamellar lipid vesicles containing a high concentration of the fluorescent dye 6-carboxyfluorescein are incubated with either frog retinas or human lymphocytes, fluroescence distributes widely throughout each cell.
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Membrane asymmetry in epithelia: is the tight junction a barrier to diffusion in the plasma membrane?
TL;DR: The ability of a lipid probe to pass the tight junction is correlated with its ability to ‘flip-flop’ to the inner monolayer of the cell membrane bilayer.
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The structure of human beta-defensin-2 shows evidence of higher order oligomerization.
David M. Hoover,Kanaghalagatta R. Rajashankar,Kanaghalagatta R. Rajashankar,Robert Blumenthal,Anu Puri,Joost J. Oppenheim,Oleg Chertov,Jacek Lubkowski +7 more
TL;DR: The structural and electrostatic properties of the hBD2 octamer support an electrostatic charge-based mechanism of membrane permeabilization by β-defensins, rather than a mechanism based on formation of bilayer-spanning pores.