O
Oleg Chertov
Researcher at Science Applications International Corporation
Publications - 49
Citations - 8815
Oleg Chertov is an academic researcher from Science Applications International Corporation. The author has contributed to research in topics: Immunotoxin & Beta defensin. The author has an hindex of 30, co-authored 49 publications receiving 8345 citations. Previous affiliations of Oleg Chertov include Leidos & National Institutes of Health.
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Journal ArticleDOI
β-Defensins: Linking Innate and Adaptive Immunity Through Dendritic and T Cell CCR6
D. Yang,Oleg Chertov,S. N. Bykovskaia,Qian Chen,M. J. Buffo,J. I. Shogan,M. Anderson,J. M. Schröder,Ji Ming Wang,O. M. Z. Howard,Joost J. Oppenheim +10 more
TL;DR: In this paper, human β-defensin was selectively chemotactic for cells stably transfected to express human CCR6, a chemokine receptor preferentially expressed by immature dendritic cells and memory T cells.
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Ll-37, the Neutrophil Granule–And Epithelial Cell–Derived Cathelicidin, Utilizes Formyl Peptide Receptor–Like 1 (Fprl1) as a Receptor to Chemoattract Human Peripheral Blood Neutrophils, Monocytes, and T Cells
De Yang,Qian Chen,Albert P. Schmidt,G. Mark Anderson,Ji Ming Wang,Joseph Wooters,Joost J. Oppenheim,Oleg Chertov +7 more
TL;DR: The results suggest that, in addition to its microbicidal activity, LL-37 may contribute to innate and adaptive immunity by recruiting neutrophils, monocytes, and T cells to sites of microbial invasion by interacting with FPRL1.
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Toll-Like Receptor 4-Dependent Activation of Dendritic Cells by β-Defensin 2
Arya Biragyn,Pier Adelchi Ruffini,Cynthia A. Leifer,Elena Klyushnenkova,Alexander Shakhov,Oleg Chertov,Aiko Konno Shirakawa,Joshua M. Farber,David M. Segal,Joost J. Oppenheim,Larry W. Kwak +10 more
TL;DR: It is demonstrated that murine β-defensin 2 (mDF2β) acts directly on immature dendritic cells as an endogenous ligand for Toll-like receptor 4 (TLR-4), inducing up-regulation of costimulatory molecules and d endritic cell maturation, suggesting that mDF2 β may play an important role in immunosurveillance against pathogens and, possibly, self antigens or tumor antigENS.
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Identification of Defensin-1, Defensin-2, and CAP37/Azurocidin as T-cell Chemoattractant Proteins Released from Interleukin-8-stimulated Neutrophils (∗)
Oleg Chertov,Dennis F. Michiel,Luoling Xu,Ji Ming Wang,Kenji Tani,William J. Murphy,Dan L. Longo,Dennis D. Taub,Joost J. Oppenheim +8 more
TL;DR: The antimicrobial proteins, CAP37/azurocidin and defensins H NP-1 and HNP-2, are identified as potent neutrophil-derived chemoattractants for T-cells, which represent primordial antimicrobial peptides which may have evolved into acute inflammatory cell-derived signals that mobilize immunocompetent T- cells and other inflammatory cells.
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Human neutrophil defensins selectively chemoattract naive T and immature dendritic cells.
TL;DR: It is shown that human neutrophil defensins selectively induce the migration of human CD4+/CD45RA+ naive and CD8+, but not CD4/ CD45RO+ memory, T cells, suggesting that, in addition to their antimicrobial role, human neutrophic defensin also contribute to adaptive immunity by mobilizing T cells and dendritic cells.