G
Gabriela M. Kuster
Researcher at University Hospital of Basel
Publications - 56
Citations - 2036
Gabriela M. Kuster is an academic researcher from University Hospital of Basel. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 20, co-authored 47 publications receiving 1749 citations. Previous affiliations of Gabriela M. Kuster include Boston Medical Center & University of Basel.
Papers
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SARS-CoV2: should inhibitors of the renin-angiotensin system be withdrawn in patients with COVID-19?
Gabriela M. Kuster,Otmar Pfister,Thilo Burkard,Qian Zhou,Raphael Twerenbold,Philip Haaf,Andreas F. Widmer,Stefan Osswald +7 more
TL;DR: In this paper, the authors proposed a method to solve the problem of the problem: this paper ] of "uniformity" of the distribution of data points in the data set.
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Outcome of elderly patients with chronic symptomatic coronary artery disease with an invasive vs optimized medical treatment strategy: one-year results of the randomized TIME trial.
Matthias Pfisterer,Peter Buser,Stefan Osswald,Urs Allemann,Wolfgang Amann,Walter Angehrn,Eric Eeckhout,Paul Erne,Werner Estlinbaum,Gabriela M. Kuster,Tiziano Moccetti,Barbara Naegeli,Peter Rickenbacher +12 more
TL;DR: 1-year outcomes in elderly patients with chronic angina are similar with regard to symptoms, quality of life, and death or nonfatal infarction with invasive vs optimized medical strategies based on this intention-to-treat analysis.
Journal ArticleDOI
Mineralocorticoid Receptor Inhibition Ameliorates the Transition to Myocardial Failure and Decreases Oxidative Stress and Inflammation in Mice With Chronic Pressure Overload
Gabriela M. Kuster,Eugene Kotlyar,Mary K. Rude,Deborah A. Siwik,Ronglih Liao,Wilson S. Colucci,Flora Sam +6 more
TL;DR: The effects of mineralocorticoid receptor stimulation are associated with alterations in the interstitial matrix and myocyte apoptosis and may be mediated, at least in part, by oxidative stress and inflammation.
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Aldosterone Stimulates Matrix Metalloproteinases and Reactive Oxygen Species in Adult Rat Ventricular Cardiomyocytes
Mary K. Rude,Toni-Ann S. Duhaney,Gabriela M. Kuster,Sharon Judge,Joline Heo,Wilson S. Colucci,Deborah A. Siwik,Flora Sam +7 more
TL;DR: Aldosterone induces MMP activity in ARVM via activation of the mineralocorticoid receptor, PKC, and ROS-dependentactivation of the MEK/ERK pathway, and NADPH oxidase is a likely source of ROS in this system.
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Redox-mediated reciprocal regulation of SERCA and Na+–Ca2+ exchanger contributes to sarcoplasmic reticulum Ca2+ depletion in cardiac myocytes
Gabriela M. Kuster,Steve Lancel,Jingmei Zhang,Catherine Communal,Mario P. Trucillo,Chee Chew Lim,Otmar Pfister,Ellen O. Weinberg,Richard A. Cohen,Ronglih Liao,Deborah A. Siwik,Wilson S. Colucci +11 more
TL;DR: In this article, the authors used an in vitro cardiomyocyte system to test the hypothesis that short-term oxidative stress induces sarcoplasmic reticulum (SR) Ca(2+) depletion via redox-mediated regulation of SERCA and the sodium-Ca(2+ exchanger (NCX) and that this was associated with thiol oxidation.