G
Gaetano Romano
Researcher at Temple University
Publications - 80
Citations - 3314
Gaetano Romano is an academic researcher from Temple University. The author has contributed to research in topics: Growth factor receptor & Stem cell. The author has an hindex of 29, co-authored 79 publications receiving 3219 citations. Previous affiliations of Gaetano Romano include Thomas Jefferson University.
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Journal ArticleDOI
Multiple signaling pathways of the insulin-like growth factor 1 receptor in protection from apoptosis.
Francesca Peruzzi,Marco Prisco,Michael Dews,Paolo Salomoni,Emanuela Grassilli,Gaetano Romano,Bruno Calabretta,Renato Baserga +7 more
TL;DR: The presence of multiple antiapoptotic pathways may explain the remarkable efficacy of the IGF-1R in protecting cells from apoptosis.
Journal Article
Differential expression of intercellular adhesion molecule 1 in primary and metastatic melanoma lesions.
P. G. Natali,Maria Rita Nicotra,R. Cavaliere,Aldo Bigotti,Gaetano Romano,Massimo Temponi,Soldano Ferrone +6 more
TL;DR: Results suggest that ICAM-1 may be a useful marker in the analysis of the molecular mechanism underlying the association between lesion thickness and clinical course of the disease.
Journal Article
Biological activities and signaling pathways of the granulin/epithelin precursor.
Tommaso Zanocco-Marani,Andrew Bateman,Gaetano Romano,Barbara Valentinis,Zhiheng He,Renato Baserga +5 more
TL;DR: GEP activates, in R- cells, the two signaling pathways that are known to be sufficient for IGF-I-mediated mitogenesis in cells overexpressing the IGF-IR, the mitogen-activated protein kinase and the phosphatidylinositol 3-kinase pathways, and confirms that, for transformation, other pathways must be activated besides the two pathway that are sufficient for mitogenesis.
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From G0 to S phase: a view of the roles played by the retinoblastoma (Rb) family members in the Rb-E2F pathway.
Ang Sun,Luigi Bagella,Luigi Bagella,Steven Tutton,Gaetano Romano,Antonio Giordano,Antonio Giordano +6 more
TL;DR: This mini‐review describes the mechanisms by which Rb family members and E2F regulate cell cycle progression and plays an essential role in regulating cell cycle and, consequently, cell proliferation.
Journal ArticleDOI
Insulin and IGF-I receptors signaling in protection from apoptosis.
TL;DR: Stably transfecting R-cells with constructs expressing the IR is shown to protect cells from apoptosis induced by anoikis or by okadaic acid, suggesting that the IGF-IR uses an alternative anti-apoptotic pathway, not shared with the IR, which is PI3-ki-independent.