S
Soldano Ferrone
Researcher at Harvard University
Publications - 1047
Citations - 45983
Soldano Ferrone is an academic researcher from Harvard University. The author has contributed to research in topics: Antigen & Monoclonal antibody. The author has an hindex of 106, co-authored 1021 publications receiving 42257 citations. Previous affiliations of Soldano Ferrone include University of Salerno & Memorial Sloan Kettering Cancer Center.
Papers
More filters
Book ChapterDOI
Escape of human solid tumors from T-cell recognition: molecular mechanisms and functional significance.
TL;DR: This important finding suggests that TAA-specific CTL may be present in some cancer patients but are unable to attack tumor cells due to the presence of inhibitory receptors.
Journal Article
Major Histocompatibility Complex Class I-related Chain A and UL16-Binding Protein Expression on Tumor Cell Lines of Different Histotypes Analysis of Tumor Susceptibility to NKG2D-dependent Natural Killer Cell Cytotoxicity
Daniela Pende,Paola Rivera,Stefania Marcenaro,Chang Chien-Chung,Roberto Biassoni,Romana Conte,Marek Kubin,David J. Cosman,Soldano Ferrone,Lorenzo Moretta,Alessandro Moretta +10 more
TL;DR: The data suggest that the involvement of NKG2D in natural killer cell-mediated cytotoxicity strictly correlates with the expression and the surface density of MICA and ULBP on target cell tumors of different histotypes.
Journal ArticleDOI
Loss of HLA class I antigens by melanoma cells: molecular mechanisms, functional significance and clinical relevance.
TL;DR: Ferrone and Marincola as mentioned in this paper reviewed defects in class I expression as described in melanoma cells, as well as the molecular mechanisms, functional significance and clinical implications of such defects.
Journal ArticleDOI
Antigen-processing machinery breakdown and tumor growth.
TL;DR: The pathophysiology of the MHC class I and II APM is described, their role in the escape of tumor cells from in vitro recognition by T cells is discussed and their role with malignant transformation of human cells is reviewed.
Journal ArticleDOI
Impaired HLA Class I Antigen Processing and Presentation as a Mechanism of Acquired Resistance to Immune Checkpoint Inhibitors in Lung Cancer
Scott N. Gettinger,Jungmin Choi,Katherine Hastings,Anna Truini,Ila Datar,Ryan T. Sowell,Anna Wurtz,Weilai Dong,Guoping Cai,Mary Ann Melnick,Victor Y. Du,Joseph Schlessinger,Sarah B. Goldberg,Anne C. Chiang,Miguel F. Sanmamed,Ignacio Melero,Jackeline Agorreta,Luis M. Montuenga,Richard P. Lifton,Soldano Ferrone,Paula B. Kavathas,David L. Rimm,Susan M. Kaech,Kurt A. Schalper,Roy S. Herbst,Katerina Politi +25 more
TL;DR: CRISPR-mediated knockout of B2m in an immunocompetent lung cancer mouse model conferred resistance to PD-1 blockade in vivo, proving its role in resistance to ICIs.