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Showing papers by "Gan-Xin Yan published in 2017"

Journal Article•DOI•
The Phenotypic Spectrum of a Mutation Hotspot Responsible for the Short QT Syndrome

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Dan Hu, Yang Li1, Jiancheng Zhang2, Ryan Pfeiffer, Michael H. Gollob3, Jeff S. Healey4, Daniel Toshio Harrell5, Naomasa Makita5, Haruhiko Abe, Yaxun Sun6, Jihong Guo7, Li Zhang8, Gan-Xin Yan8, Douglas Y. Mah9, Edward P. Walsh9, Harris Leopold10, Carla Giustetto11, Fiorenzo Gaita11, Agnieszka Zienciuk-Krajka12, Andrea Mazzanti, Silvia G. Priori13, Charles Antzelevitch8, Hector Barajas-Martinez •
Chinese PLA General Hospital1, Fujian Medical University2, Toronto General Hospital3, Population Health Research Institute4, Nagasaki University5, Zhejiang University6, Peking University7, Lankenau Institute for Medical Research8, Boston Children's Hospital9, University of Connecticut10, University of Turin11, Gdańsk Medical University12, University of Pavia13
01 Jul 2017-JACC: Clinical Electrophysiology
TL;DR: The clinical characteristics and biophysical properties of the highly frequent mutation that contributes to genetically identified SQTS probands are reported, and the understanding of the spectrum of KCNH2 channel defects in SQTS is extended.

35 citations

Journal Article•DOI•
Synergistic Effect of Dofetilide and Mexiletine on Prevention of Atrial Fibrillation.

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Guizhi Liu1, Xiaolin Xue2, Chuanyu Gao1, Jiaqi Huang3, Datun Qi1, Yanzhou Zhang1, Jianzeng Dong1, Changsheng Ma4, Gan-Xin Yan2 •
Zhengzhou University1, Xi'an Jiaotong University2, Lankenau Institute for Medical Research3, Capital Medical University4
18 May 2017-Journal of the American Heart Association
TL;DR: In rabbits, combined use of dofetilide and mexiletine not only synergistically increases atrial ERP and effectively suppresses AF inducibility, but also markedly reduces QT liability and torsade de pointes risk posed by do Fetilide alone.
Abstract: BackgroundAlthough atrial fibrillation (AF) is the most common abnormal heart rhythm and its prevalence continues to rise, there is a marked paucity of effective and safe antiarrhythmic drugs for A

5 citations