G
Gareth R. Tibbs
Researcher at Columbia University
Publications - 26
Citations - 3142
Gareth R. Tibbs is an academic researcher from Columbia University. The author has contributed to research in topics: HCN channel & Gating. The author has an hindex of 15, co-authored 25 publications receiving 2989 citations. Previous affiliations of Gareth R. Tibbs include Howard Hughes Medical Institute & Cornell University.
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Journal ArticleDOI
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
Bina Santoro,David T. Liu,Huan Yao,Huan Yao,Dusan Bartsch,Eric R. Kandel,Eric R. Kandel,Steven A. Siegelbaum,Steven A. Siegelbaum,Gareth R. Tibbs +9 more
TL;DR: Heterologous expression of mBCNG-1 demonstrates that it does indeed code for a channel with properties indistinguishable from pacemaker channels in brain and similar to those in heart, demonstrating that these channels constitute a widely expressed gene family.
Journal ArticleDOI
Molecular and Functional Heterogeneity of Hyperpolarization-Activated Pacemaker Channels in the Mouse CNS
Bina Santoro,Shan Chen,Anita Lüthi,Paul Pavlidis,Gleb P. Shumyatsky,Gareth R. Tibbs,Steven A. Siegelbaum +6 more
TL;DR: Comparisons of mRNA expression with an electrophysiological characterization of nativeIh currents in hippocampal and thalamic neurons support the idea that the functional heterogeneity of Ih channels is attributable, in part, to differential isoform expression.
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Molecular mechanism of cAMP modulation of HCN pacemaker channels
TL;DR: It is demonstrated by constructing truncation mutants that the CNBD inhibits activation of the core transmembrane domain and cAMP binding relieves this inhibition, resulting in differences in activation gating and extent of cAMP modulation between the HCN1 and HCN2 isoforms.
Journal ArticleDOI
The HCN gene family: molecular basis of the hyperpolarization-activated pacemaker channels.
Bina Santoro,Gareth R. Tibbs +1 more
TL;DR: The molecular basis of the hyperpolarization‐activated cation channels that underlie the anomalous rectifying current variously termed Ih, Iq, or If is discussed and an initial attempt at defining the identity and subunit composition of channels underlying native Ih is undertaken.
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Subunit Stoichiometry of Cyclic Nucleotide-Gated Channels and Effects of Subunit Order on Channel Function
TL;DR: The data demonstrate that cyclic nucleotide-gated ion channels are tetrameric like the related voltage- gated potassium ion channels; the order of subunits affects the conductance of the channel; and the channel has 4-fold symmetry in which four asymmetric subunits assemble head to tail around a central axis.