S
Steven A. Siegelbaum
Researcher at Columbia University
Publications - 101
Citations - 12223
Steven A. Siegelbaum is an academic researcher from Columbia University. The author has contributed to research in topics: Hippocampal formation & Excitatory postsynaptic potential. The author has an hindex of 51, co-authored 92 publications receiving 11116 citations. Previous affiliations of Steven A. Siegelbaum include Columbia University Medical Center & Howard Hughes Medical Institute.
Papers
More filters
Journal ArticleDOI
Hyperpolarization-Activated Cation Currents: From Molecules to Physiological Function
TL;DR: The relation between the biophysical properties of recombinant HCN channels and the pattern of HCN mRNA expression with the properties of native Ih in neurons and cardiac muscle is reviewed.
Journal ArticleDOI
Identification of a gene encoding a hyperpolarization-activated pacemaker channel of brain.
Bina Santoro,David T. Liu,Huan Yao,Huan Yao,Dusan Bartsch,Eric R. Kandel,Eric R. Kandel,Steven A. Siegelbaum,Steven A. Siegelbaum,Gareth R. Tibbs +9 more
TL;DR: Heterologous expression of mBCNG-1 demonstrates that it does indeed code for a channel with properties indistinguishable from pacemaker channels in brain and similar to those in heart, demonstrating that these channels constitute a widely expressed gene family.
Journal ArticleDOI
Serotonin and cyclic AMP close single K+ channels in Aplysia sensory neurones.
TL;DR: A serotonin-sensitive K+ channel with novel properties is identified that can account for the increases in the duration of the action potential, Ca2+ influx, and transmitter release which underlie behavioural sensitization, a simple form of learning.
Journal ArticleDOI
Lipoxygenase metabolites of arachidonic acid as second messengers for presynaptic inhibition of Aplysia sensory cells.
Daniele Piomelli,Andrea Volterra,Nicholas Dale,Steven A. Siegelbaum,Eric R. Kandel,James H. Schwartz,Francesco Belardetti,Francesco Belardetti +7 more
TL;DR: Biochemical and biophysical studies on Aplysia sensory neurons indicate that inhibitory responses to the molluscan peptide FMRFamide are mediated by lipoxygenase metabolites of arachidonic acid, which are a new class of second messengers in neurons.
Journal ArticleDOI
A Behavioral Role for Dendritic Integration: HCN1 Channels Constrain Spatial Memory and Plasticity at Inputs to Distal Dendrites of CA1 Pyramidal Neurons
Matthew F. Nolan,Gaël Malleret,Josh T. Dudman,Derek L. Buhl,Bina Santoro,Emma Gibbs,Svetlana Vronskaya,György Buzsáki,Steven A. Siegelbaum,Eric R. Kandel,Alexei Morozov +10 more
TL;DR: It is suggested that HCN1 channels constrain learning and memory by regulating dendritic integration of distal synaptic inputs to pyramidal cells.