G
Gareth T. Williams
Researcher at Laboratory of Molecular Biology
Publications - 40
Citations - 6435
Gareth T. Williams is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Antigen & Somatic hypermutation. The author has an hindex of 29, co-authored 40 publications receiving 6313 citations.
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Journal ArticleDOI
Comparison of the effector functions of human immunoglobulins using a matched set of chimeric antibodies.
Marianne Brüggemann,Gareth T. Williams,C Bindon,Mike Clark,M R Walker,R Jefferis,Herman Waldmann,Michael S. Neuberger +7 more
TL;DR: The results suggest that IgG1 might be the favoured IgG subclass for therapeutic applications in complement-dependent hemolysis and in antibody-dependent cell-mediated cytotoxicity using both human effector and human target cells.
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Recombinant antibodies possessing novel effector functions
TL;DR: Cell lines have been established that secrete hapten-specific antibodies in which the Fc portion has been replaced either with an active enzyme moiety or with polypeptide displaying c-myc antigenic determinants.
Journal ArticleDOI
Immunoglobulin Isotype Switching Is Inhibited and Somatic Hypermutation Perturbed in UNG-Deficient Mice
Cristina Rada,Gareth T. Williams,Hilde Nilsen,Deborah E. Barnes,Tomas L Lindahl,Michael S. Neuberger +5 more
TL;DR: The results provide strong support for the DNA deamination model for antibody diversification with respect to class-switching as well as hypermutation and suggest that UNG is the major mouse DNA glycosylase responsible for processing the programmed dU/dG lesions within the immunoglobulin locus.
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Hyperresponsive B Cells in CD22-Deficient Mice
TL;DR: CD22 is a negative regulator of antigen receptor signaling whose onset of expression at the mature B cell stage may serve to raise the antigen concentration threshold required for B cell triggering.
Journal ArticleDOI
A hapten-specific chimaeric IgE antibody with human physiological effector function.
Michael S. Neuberger,Gareth T. Williams,E. B. Mitchell,S. S. Jouhal,John G. Flanagan,Terence H. Rabbitts +5 more
TL;DR: The emergence of techniques allowing the stable introduction of immunoglobulin gene DNA into myeloma cells3–5 has allowed us to construct a mouse cell line that secretes a chimaeric IgE, λ1 antibody whose heavy chain is composed of a human Cε constant region fused to a mouse variable (VH) region.