G
Gareth W. Roberts
Researcher at Imperial College London
Publications - 43
Citations - 4952
Gareth W. Roberts is an academic researcher from Imperial College London. The author has contributed to research in topics: Temporal lobe & Hippocampus. The author has an hindex of 24, co-authored 43 publications receiving 4877 citations. Previous affiliations of Gareth W. Roberts include University of Washington.
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Journal ArticleDOI
Distinct sites of intracellular production for Alzheimer's disease A beta40/42 amyloid peptides.
Tobias Hartmann,Sophie Bieger,Babara Brühl,Pentti J. Tienari,Nobuo Ida,David Allsop,Gareth W. Roberts,Colin L. Masters,Carlos G. Dotti,Klaus Unsicker,Konrad Beyreuther +10 more
TL;DR: The specific production of the critical Aβ isoform in the ER of neurons links this compartment with the generation of Aβ and explains why primarily ER localized (mutant) proteins such as the presenilins3 could induce AD.
Journal ArticleDOI
Neuropeptide Y distribution in human brain
Thomas E. Adrian,J.M. Allen,Stephen R. Bloom,M. A. Ghatei,Martin N. Rossor,Gareth W. Roberts,T. J. Crow,K. Tatemoto,J. M. Polak +8 more
TL;DR: NPY, a newly discovered peptide with potent biological activity, seems to be among the most abundant of human neuropeptides, being particularly concentrated in the basal ganglia, amygdala and nucleus accum-bens.
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Schizophrenia as an Anomaly of Development of Cerebral Asymmetry: A Postmortem Study and a Proposal Concerning the Genetic Basis of the Disease
T. J. Crow,Ball J,Rosemary Brown,Clive Bruton,N. Colter,Chris D. Frith,Eve C. Johnstone,Owens Dg,Gareth W. Roberts +8 more
TL;DR: A postmortem study finds that ventricular enlargement affects the posterior and particularly the temporal horn of the lateral cerebral ventricle, consistent with the view that schizophrenia is a disorder of the genetic mechanisms that control the development of cerebral asymmetry.
Journal ArticleDOI
Apolipoprotein E epsilon 4 allele is associated with deposition of amyloid beta-protein following head injury.
TL;DR: This finding provides further evidence linking apo E-ε4 with Aβ deposition in vivo and suggests that known environmental and genetic risk factors for Alzheimer's disease may act additively and indicates a genetic susceptibility to the effects of a head injury.
Journal ArticleDOI
Neuropeptides in Alzheimer type dementia
I. N. Ferrier,Alan J. Cross,J. A. Johnson,Gareth W. Roberts,T. J. Crow,J. A. N. Corsellis,YC Lee,D.J. O’Shaughnessy,Thomas E. Adrian,Gerard P. McGregor,A.J. Baracese-Hamilton,S.R. Bloom +11 more
TL;DR: Levels of SRIF, but not those of the other peptides, were reduced in several cortical areas in Alzheimer-type dementia (ATD), and NT and SRIF were significantly, and VIP and SP non-significantly, reduced in the septum in ATD.