G
Garrit Koller
Researcher at King's College London
Publications - 46
Citations - 1081
Garrit Koller is an academic researcher from King's College London. The author has contributed to research in topics: Medicine & Root canal. The author has an hindex of 17, co-authored 42 publications receiving 857 citations. Previous affiliations of Garrit Koller include Guy's Hospital & HealthPartners.
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ADAM8 as a drug target in pancreatic cancer
Uwe Schlomann,Garrit Koller,Catharina Conrad,Taheera Ferdous,Panagiota Golfi,Adolfo Molejon Garcia,Sabrina Höfling,Maddy Parsons,Patricia Costa,Robin Soper,Maud Bossard,Thorsten Hagemann,Rozita Roshani,Norbert Sewald,Randal R. Ketchem,Marcia L. Moss,Fred H. Rasmussen,David A. Tuveson,Christopher Nimsky,Jörg W. Bartsch,Miles A. Miller,Douglas A. Lauffenburger +21 more
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Tumor Necrosis Factor-α (TNF-α) regulates shedding of TNF-α receptor 1 by the metalloprotease-disintegrin ADAM8: Evidence for a protease-regulated feedback loop in neuroprotection
Joerg W. Bartsch,Dirk Wildeboer,Garrit Koller,Silvia Naus,Andrea Rittger,Marcia L. Moss,Yuji Minai,Harald Jockusch +7 more
TL;DR: The results indicate an essential role for ADAM8 in modulating TNF-α signaling in CNS diseases: a feedback loop integrating T NF-α,ADAM8, and TNF/R1 shedding as a plausible mechanism for TNF -α mediated neuroprotection in situ and a rationale for therapeutic intervention.
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The pathway to intelligent implants: osteoblast response to nano silicon-doped hydroxyapatite patterning.
TL;DR: The silicon addition provides an extra chemical cue to stimulate and enhance bone formation for new generation coatings, and the next stage in metallic implantation design is to further improve cellular adhesion and proliferation by control of cell alignment.
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The metalloprotease-disintegrin ADAM8 contributes to temozolomide chemoresistance and enhanced invasiveness of human glioblastoma cells.
Fangyong Dong,Michael Eibach,Jörg W. Bartsch,Amalia M. Dolga,Uwe Schlomann,Catharina Conrad,Susanne Schieber,Oliver Schilling,Martin L. Biniossek,Carsten Culmsee,Herwig Strik,Garrit Koller,Barbara Carl,Christopher Nimsky +13 more
TL;DR: AdAM8 causes TMZ resistance in GBM cells by enhancing pAkt/PI3K, pERK1/2, and cleavage of CD44 and HGF R/c-met, and specific ADAM8 inhibition can optimize TMZ chemotherapy of GBM in order to prevent formation of recurrent G BM in patients.
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A novel jet-based nano-hydroxyapatite patterning technique for osteoblast guidance
Xiang Li,Garrit Koller,Jie Huang,Lucy Di Silvio,Tara Renton,Minoo Esat,William Bonfield,William Bonfield,Mohan Edirisinghe +8 more
TL;DR: In vitro studies showed that the nHA patterns generated are capable of regulating the human osteoblast cell attachment and orientation, and were able to influence cellular responses to an implant material.