O
Oliver Schilling
Researcher at University of Freiburg
Publications - 174
Citations - 7400
Oliver Schilling is an academic researcher from University of Freiburg. The author has contributed to research in topics: Proteome & Proteases. The author has an hindex of 38, co-authored 152 publications receiving 5693 citations. Previous affiliations of Oliver Schilling include National and Kapodistrian University of Athens & European Bioinformatics Institute.
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Journal ArticleDOI
Biological role of matrix metalloproteinases: a critical balance
TL;DR: Advancing the understanding of the MMP contribution to tissue homeostasis will lead to identify causal relationships between their dysregulation and the development of disease pathologies, thus guiding us to successful MMP-directed therapies.
Journal ArticleDOI
Isotopic labeling of terminal amines in complex samples identifies protein N-termini and protease cleavage products
Oded Kleifeld,Alain Doucet,Ulrich auf dem Keller,Anna Prudova,Oliver Schilling,Rajesh K. Kainthan,Amanda E. Starr,Leonard J. Foster,Jayachandran N. Kizhakkedathu,Christopher M. Overall +9 more
TL;DR: The approach, named terminal amine isotopic labeling of substrates (TAILS), addresses this challenge by using dendritic polyglycerol aldehyde polymers that remove tryptic and C-terminal peptides to discriminate between the substrates of the protease of interest and the products of background proteolysis.
Journal ArticleDOI
OpenMS: a flexible open-source software platform for mass spectrometry data analysis
Hannes L. Röst,Hannes L. Röst,Timo Sachsenberg,Stephan Aiche,Chris Bielow,Hendrik Weisser,Fabian Aicheler,Sandro Andreotti,Hans-Christian Ehrlich,Petra Gutenbrunner,Erhan Kenar,Xiao Liang,Sven Nahnsen,Lars Nilse,Julianus Pfeuffer,George Rosenberger,Marc Rurik,Uwe Schmitt,Johannes Veit,Mathias Walzer,David Wojnar,Witold Wolski,Oliver Schilling,Jyoti S. Choudhary,Lars Malmström,Lars Malmström,Ruedi Aebersold,Ruedi Aebersold,Knut Reinert,Knut Reinert,Oliver Kohlbacher +30 more
TL;DR: OpenMS 2.0 is presented, a robust, open-source, cross-platform software specifically designed for the flexible and reproducible analysis of high-throughput MS data.
Journal ArticleDOI
Proteome-derived, database-searchable peptide libraries for identifying protease cleavage sites.
TL;DR: This work introduced human proteome–derived, database-searchable peptide libraries for characterizing sequence-specific protein interactions, and used peptides in such libraries with protected primary amines to simultaneously determine sequence preferences on the N-terminal (nonprime P) and C-terminals of the scissile bond.
Journal ArticleDOI
Stromal Microenvironment Shapes the Intratumoral Architecture of Pancreatic Cancer
Matteo Ligorio,Srinjoy Sil,Jose Malagon-Lopez,Linda T. Nieman,Sandra Misale,Mauro Di Pilato,Richard Y. Ebright,Murat Karabacak,Anupriya S. Kulkarni,A. W. K. Liu,Nicole Vincent Jordan,Joseph W. Franses,Julia Philipp,Johannes Kreuzer,Niyati Desai,Kshitij S. Arora,Mihir Rajurkar,Elad Horwitz,Azfar Neyaz,Eric Tai,Neelima K.C. Magnus,Kevin D. Vo,Chittampalli Yashaswini,Francesco Marangoni,Myriam Boukhali,Jackson P. Fatherree,Leah J. Damon,Kristina Xega,Rushil Desai,Melissa Choz,Francesca Bersani,Adam Langenbucher,Vishal Thapar,Robert Morris,Ulrich F. Wellner,Oliver Schilling,Michael S. Lawrence,Andrew S. Liss,Miguel Rivera,Vikram Deshpande,Cyril H. Benes,Shyamala Maheswaran,Daniel A. Haber,Daniel A. Haber,Carlos Fernandez-del-Castillo,Cristina R. Ferrone,Wilhelm Haas,Martin J. Aryee,David T. Ting +48 more
TL;DR: The impact of the stroma is demonstrated in shaping tumor architecture by altering inherent patterns of tumor glands in human PDAC by quantifying EMT and PRO subpopulations in 319,626 individual cancer cells that can be classified within the context of distinct tumor gland "units".