C
Carsten Culmsee
Researcher at University of Marburg
Publications - 172
Citations - 13392
Carsten Culmsee is an academic researcher from University of Marburg. The author has contributed to research in topics: Neuroprotection & Programmed cell death. The author has an hindex of 60, co-authored 166 publications receiving 11846 citations. Previous affiliations of Carsten Culmsee include University of Giessen & Ludwig Maximilian University of Munich.
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Journal ArticleDOI
Glutathione Peroxidase 4 Senses and Translates Oxidative Stress into 12/15-Lipoxygenase Dependent- and AIF-Mediated Cell Death
Alexander Seiler,Manuela Schneider,Heidi Förster,Stephan Roth,Eva K. Wirth,Carsten Culmsee,Nikolaus Plesnila,Elisabeth Kremmer,Olof Rådmark,Wolfgang Wurst,Georg W. Bornkamm,Ulrich Schweizer,Marcus Conrad +12 more
TL;DR: It is demonstrated that oxidative stress is sensed and transduced by glutathione peroxidase 4 (GPx4) into a-yet-unrecognized cell-death pathway, and the identified pathway reveals promising targets for future therapies.
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Homocysteine Elicits a DNA Damage Response in Neurons That Promotes Apoptosis and Hypersensitivity to Excitotoxicity
Inna I. Kruman,Carsten Culmsee,Sic L. Chan,Yuri Kruman,Zhihong Guo,LaRoy P. Penix,Mark P. Mattson,Mark P. Mattson +7 more
TL;DR: The PARP inhibitor 3-aminobenzamide (3AB) protects neurons against homocysteine-induced NAD depletion, loss of mitochondrial transmembrane potential, and cell death, demonstrating a requirement for PARP activation and/or NAD depletion in homocystite-induced apoptosis.
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Roles of Nuclear Factor κB in Neuronal Survival and Plasticity
TL;DR: The NF-kappaB was first shown to mediate anti-apoptotic actions of tumor necrosis factor in cultured neurons and was subsequently shown to prevent death of various nonneuronal cells.
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Purification of polyethylenimine polyplexes highlights the role of free polycations in gene transfer.
Sabine Boeckle,Katharina von Gersdorff,Silke van der Piepen,Carsten Culmsee,Ernst Wagner,Manfred Ogris +5 more
TL;DR: Nonviral vectors based on polyethylenimine usually contain an excess of PEI that is not complexed to DNA, which contributes to cellular and systemic toxicity, and purification of polyplexes from unbound PEI is desirable.
Journal ArticleDOI
p53 in neuronal apoptosis.
Carsten Culmsee,Mark P. Mattson +1 more
TL;DR: Preclinical data suggest that agents that inhibit p53 may be effective therapeutics for several neurodegenerative conditions.