G
Garth Powis
Researcher at Discovery Institute
Publications - 195
Citations - 12010
Garth Powis is an academic researcher from Discovery Institute. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 57, co-authored 194 publications receiving 11475 citations. Previous affiliations of Garth Powis include University of Texas Health Science Center at Houston & Mayo Clinic.
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Purification of human thioredoxin reductase: Properties and characterization by absorption and circular dichroism spectroscopy
TL;DR: Results of this study show that purified human TR is a relatively thermostable flavoenzyme whose tightly bound FAD group is not displaced by elevated temperatures up to 60 degrees C or by relatively low concentrations of guanidine hydrochloride.
Journal Article
Diaryl chalcogenides as selective inhibitors of thioredoxin reductase and potential antitumor agents.
Lars Engman,Ian A. Cotgreave,Miguel Angulo,Charles W. Taylor,Gillian Paine-Murrieta,Garth Powis +5 more
TL;DR: A series of 12 organoselenium compounds and 16 organotellurium compounds are examined as inhibitors of human thioredoxin reductase and the cytotoxicity and antitumor activity of some of the compounds are investigated.
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OSU-03012 promotes caspase-independent but PERK-, cathepsin B-, BID-, and AIF-dependent killing of transformed cells.
Adly Yacoub,Margaret A. Park,David Hanna,Young Hong,Clint Mitchell,Aditi P. Pandya,Hisashi Harada,Garth Powis,Ching-Shih Chen,Costas Koumenis,Steven Grant,Paul Dent +11 more
TL;DR: It is demonstrated that OSU-03012 promotes glioma cell killing that is dependent on endoplasmic reticulum stress, lysosomal dysfunction, and BID-dependent release of AIF from mitochondria, and whose lethality is enhanced by irradiation or by inhibition of protective signaling pathways.
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Human thioredoxin homodimers: regulation by pH, role of aspartate 60, and crystal structure of the aspartate 60 --> asparagine mutant.
John F. Andersen,David A. R. Sanders,John R. Gasdaska,Andrzej Weichsel,Garth Powis,William R. Montfort +5 more
TL;DR: The values obtained for Kapp suggest human thioredoxin may dimerize in vivo and possible roles for such dimers are discussed.
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Novel Water-Soluble Diorganyl Tellurides with Thiol Peroxidase and Antioxidant Activity
TL;DR: Although many of the compounds showed high catalytic activity, it was not possible to rationalize their relative efficiency and the capacity of the novel organotellurium compounds to act as a scavengers of 1,1-diphenyl-2-picrylhydrazyl was investigated.