G
Garth Powis
Researcher at Discovery Institute
Publications - 195
Citations - 12010
Garth Powis is an academic researcher from Discovery Institute. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 57, co-authored 194 publications receiving 11475 citations. Previous affiliations of Garth Powis include University of Texas Health Science Center at Houston & Mayo Clinic.
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Journal ArticleDOI
PLEKHA7 signaling is necessary for the growth of mutant KRAS driven colorectal cancer.
Hei-Cheul Jeung,Roisin Puentes,Alexander E. Aleshin,Martin Indarte,Ricardo G. Correa,Laurie A. Bankston,Fabiana I.A.L. Layng,Zamal Ahmed,Ignacio I. Wistuba,Yong Yao,Daniela G. Duenas,Shuxing Zhang,Emmanuelle J. Meuillet,Francesca M. Marassi,Robert C. Liddington,Lynn Kirkpatrick,Garth Powis +16 more
TL;DR: Plekha7 (Pleckstrin homology [PH] domain containing, family A member 7) regulates the assembly of proteins of the cytoplasmic apical zonula adherens junction (AJ), thus ensuring cell-cell adhesion and tight-junction barrier integrity as discussed by the authors.
Journal Article
The metabolism and disposition of aniline in the isolated blood-perfused liver of the rat
Alan R. Boobis,Garth Powis +1 more
TL;DR: In the isolated, blood-perfused liver of the rat, aniline is removed from the perfusion medium rapidly over the first 60 min, but more slowly over the following 120 min, while SKF 525-A, 0.2 mM, completely blocks the formation of p-aminophenol and inhibits the Formation of the acid-labile anilines conjugate by 62%.
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Gas chromatographic assay for the new antitumor agent sulfamic acid diester (NSC 329680) and its stability in buffer, blood and plasma.
TL;DR: A sensitive gas chromatographic assay with electron-capture detection has been developed for sulfamic acid diester based on its conversion to 1,7-diiodoheptane in the presence of excess sodium iodide.
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Inhibitors of Phospholipid Intracellular Signaling as Antiproliferative Agents
TL;DR: In this paper, a small number of compounds were developed as anticancer agents that may act by inhibiting growth factor signaling pathways, although their selectivity for tumor cells compared to normal tissue remains to be investigated fully in appropriate animal tumor models.
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Isolation, identification and biological activity of a phyllanthoside metabolite produced in vitro by mouse plasma
TL;DR: Results suggest that aglycone formation occurs as a result of plasma esterase activity, and the toxicity of phyllanthoside, and perhaps its efficacy as an antitumor agent in mice, may depend on its rate of conversion to the agly cone.