G
Garth Powis
Researcher at Discovery Institute
Publications - 195
Citations - 12010
Garth Powis is an academic researcher from Discovery Institute. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 57, co-authored 194 publications receiving 11475 citations. Previous affiliations of Garth Powis include University of Texas Health Science Center at Houston & Mayo Clinic.
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Journal ArticleDOI
Superoxide dismutase is regulated by LAMMER kinase in Drosophila and human cells.
TL;DR: The data suggest that SOD1 is negatively regulated by LAMMER kinases in Drosophila and human cell lines and that this regulation may be conserved during evolution.
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Synthesis of 1D-3-deoxy- and -2,3-dideoxyphosphatidylinositol
TL;DR: Both 1 d -3-deoxy- and -2,3-dideoxyphosphatidylinositol (3 and 18) were synthesized using the regioisomeric mixture of viburnitol 1,2:4,5- and 1:5,6- diacetonides as starting material.
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The Use of Human Liver for Foreign Compound Metabolism and Toxicity Studies
TL;DR: The use of human liver for Foreign Compound Metabolism and Toxicity Studies was discussed in this paper, where the authors proposed a method to identify the most likely compound for foreign compound studies.
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Structural basis for the association of PLEKHA7 with membrane-embedded phosphatidylinositol lipids
Alexander E. Aleshin,Yong Yao,Amer Iftikhar,Andrey A. Bobkov,Jinghua Yu,Gregory W. Cadwell,Michael G. Klein,Chuqiao Dong,Laurie A. Bankston,Robert C. Liddington,Wonpil Im,Garth Powis,Francesca M. Marassi +12 more
TL;DR: It is shown – in atomic-level detail – that the interaction of PLEKHA7 with PIPs is multivalent and induces PIP clustering, and the PIP binding mechanism is distinct from a discrete one-to-one interaction.
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Synthesis and biological activity of the D-3-deoxy-3-fluoro and D-3-chloro-3-deoxy analogues of phosphatidylinositol
Alan P. Kozikowski,Alan P. Kozikowski,Garth Powis,Abdul H. Fauq,Abdul H. Fauq,Werner Tückmantel,Werner Tückmantel,Alfred Gallegos,Alfred Gallegos +8 more
TL;DR: Compounds 4 and 28 exhibit moderate and high selectivity, respectively, in the growth inhibition of υ-sis transformed vs wild type murine NIH 3T3 cells if myo-inositol is agent but are inactive in the presence of physiological inositol levels.