G
Garth Powis
Researcher at Discovery Institute
Publications - 195
Citations - 12010
Garth Powis is an academic researcher from Discovery Institute. The author has contributed to research in topics: Thioredoxin & Thioredoxin reductase. The author has an hindex of 57, co-authored 194 publications receiving 11475 citations. Previous affiliations of Garth Powis include University of Texas Health Science Center at Houston & Mayo Clinic.
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Molecular pharmacology and antitumor activity of palmarumycin-based inhibitors of thioredoxin reductase
TL;DR: X-916 as discussed by the authors, a water-soluble prodrug of a palmarumycin CP1 analogue, has been shown to be a potent inhibitor of purified human thioredoxin reductase-1.
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Thioredoxin reductase and cancer cell growth inhibition by organotellurium antioxidants.
TL;DR: Novel organotellurium antioxidants, especially a primitive analog of vitamin E and compounds 7, 9 and 10—all carrying highly functionalized 4-(dialkylamino)phenyltelluro groups to secure high antioxidative capacity—were found to inhibit TrxR with IC50 values in the low micromolar range.
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Cryopreservation of rat and dog hepatocytes for studies of xenobiotic metabolism and activation.
TL;DR: Using rat and dog isolated hepatocytes, a procedure for cryopreserved hepatocytes in large numbers such as are needed for metabolism and toxicity studies is developed.
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ERK5 signalling rescues intestinal epithelial turnover and tumour cell proliferation upon ERK1/2 abrogation.
Petrus R. de Jong,Petrus R. de Jong,Koji Taniguchi,Koji Taniguchi,Koji Taniguchi,Alexandra R. Harris,Samuel Bertin,Naoki Takahashi,Naoki Takahashi,Jen Duong,Alejandro D. Campos,Garth Powis,Maripat Corr,Michael Karin,Eyal Raz +14 more
TL;DR: It is suggested that ERK5 provides a common bypass route in intestinal epithelial cells, which rescues cell proliferation upon abrogation of ERK1/2 signalling, with therapeutic implications in CRC.
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Water-soluble organotellurium compounds inhibit thioredoxin reductase and the growth of human cancer cells.
TL;DR: Water-soluble organotellurium compounds of the diaryl telluride, alkyl arylTelluride and dialkyl tellURide type, carrying sulfopropyl groups, were found to be the most efficient tellurium-based inhibitors of thioredoxin reductase ever tested.