G
Gary Allenby
Researcher at Hoffmann-La Roche
Publications - 17
Citations - 2556
Gary Allenby is an academic researcher from Hoffmann-La Roche. The author has contributed to research in topics: Retinoic acid & Retinoic acid receptor alpha. The author has an hindex of 13, co-authored 17 publications receiving 2503 citations. Previous affiliations of Gary Allenby include Medical Research Council & Loughborough University.
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Journal ArticleDOI
9-cis retinoic acid stereoisomer binds and activates the nuclear receptor RXR alpha.
Arthur A. Levin,Laurie J. Sturzenbecker,Sonja Kazmer,Thomas Bosakowski,Christine Huselton,Gary Allenby,J Speck,C Kratzeisen,Michael Rosenberger,Allen John Lovey +9 more
TL;DR: The identification of a stereoisomer of retinoic acid, 9-cis retinol, which directly binds and activates RXRα, which suggests a new role for isomerization in the physiology of natural retinoids.
Journal ArticleDOI
Retinoic acid receptors and retinoid X receptors: interactions with endogenous retinoic acids
Gary Allenby,M T Bocquel,M Saunders,Sonja Kazmer,J Speck,Michael Rosenberger,Allen John Lovey,Philippe Kastner,Joseph F. Grippo,Pierre Chambon +9 more
TL;DR: 9-cis forms of endogenous retinoid can contribute to the pleiotropic effects of retinoids by interacting with both the RARs and RXRs.
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Evidence that secretion of immunoactive inhibin by seminiferous tubules from the adult rat testis is regulated by specific germ cell types: correlation between in vivo and in vitro studies.
TL;DR: To confirm that the changes observed in vivo after MAA treatment were indicative of changes in Sertoli rather than Leydig cell secretion of immonoactive inhibin, its secretion by isolated ST was assessed, and a pattern of change similar to that in plasma was observed.
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Binding of 9-cis-retinoic acid and all-trans-retinoic acid to retinoic acid receptors alpha, beta, and gamma. Retinoic acid receptor gamma binds all-trans-retinoic acid preferentially over 9-cis-retinoic acid.
TL;DR: Binding kinetics in vitro and in whole cells suggest that there could be differences in the interactions of the receptor subtypes with the endogenous retinoic acids under physiologic conditions.
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New retinoid X receptor subtypes in zebra fish (Danio rerio) differentially modulate transcription and do not bind 9-cis retinoic acid
TL;DR: Two additional RXR subtypes isolated from zebra fish cDNA libraries are described here; although both subtypes form DNA-binding heterodimers with RARs and TR, neither binds 9-cis RA, and both are transcriptionally inactive on RXR response elements.