Gary Britton

TL;DR: It is shown for the first time that binding of vascular endothelial growth factor to the neuropilin-1 b1 domain is essential for VEGF complex formation with VEGFR2/KDR and is important for endothelial cell migration and tubulogenesis.

TL;DR: It is reported that p130Cas tyrosine phosphorylation is stimulated by hepatocyte growth factor and platelet-derived growth factor in U87MG glioma cells and VEGF in endothelial cells and is dependent on NRP1 via its intracellular domain and identified a critical role for a novel N RP1-p130Cas pathway in the regulation of chemotaxis.

TL;DR: Findings identify a novel pathway for VEGF-induced HSP27 serine 82 phosphorylation via PKC-mediated PKD activation and direct phosphorylated of HSP 27 by PKD, and show that PKDs and HSP26 play major roles in the angiogenic response to VEGf.

TL;DR: Findings indicate that Egr3 has an essential downstream role in VEGF-mediated endothelial functions leading to angiogenesis and may have particular relevance for adult angiogenic processes involved in vascular repair and neovascular disease.

TL;DR: Findings indicate a cardinal role for assembly of the p130Cas interactome in mediating the cell migratory response to VEGF in angiogenesis, and provide a basis for further studies of p130 Cas in cell movement.