G
Gary K. Scott
Researcher at Buck Institute for Research on Aging
Publications - 76
Citations - 33574
Gary K. Scott is an academic researcher from Buck Institute for Research on Aging. The author has contributed to research in topics: Estrogen receptor & Cancer. The author has an hindex of 40, co-authored 74 publications receiving 29688 citations. Previous affiliations of Gary K. Scott include Queen's University & University of California, San Francisco.
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Journal ArticleDOI
Ets regulation of the erbB2 promoter.
Gary K. Scott,Chuan-H Chang,Katrina M Erny,Fan Xu,William J. Fredericks,Frank J. Rauscher,Ann D. Thor,Christopher C. Benz +7 more
TL;DR: Elf-1 is now shown to be another endogenously expressed Ets candidate capable of binding to and upregulating the erbB2 promoter, and new results suggesting that Ets binding induces severe promoter bending that may restrict local triplex formation are presented.
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Estrogen-induced post-transcriptional modulation of c-myc proto-oncogene expression in human breast cancer cells.
TL;DR: Results indicate that post-transcriptional modulation of c-myc by E2 is mediated by a labile degradative protein or otherwise dependent on active protein synthesis, and suggest that in ER-positive breast cancer cells, E2 can modulate c- myc mRNA levels by a post- transcriptional mechanism that depends on gene sequences upstream from c-Myc exon 2.
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Systematic Mapping of Posttranslational Modifications in Human Estrogen Receptor-α with Emphasis on Novel Phosphorylation Sites
Christian Atsriku,David Britton,Jason M. Held,Birgit Schilling,Gary K. Scott,Bradford W. Gibson,Bradford W. Gibson,Christopher C. Benz,Christopher C. Benz,Michael A. Baldwin,Michael A. Baldwin +10 more
TL;DR: Greater knowledge of this array of posttranslational modifications of estrogen receptor, particularly phosphorylation, will increase understanding of the processes that lead to estradiol-induced activation of this protein and may aid the development of therapeutic strategies for management of hormone-dependent breast cancer.
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Age-Dependent Changes in Breast Cancer Hormone Receptors and Oxidant Stress Markers
Judy N. Quong,Serenella Eppenberger-Castori,Dan H. Moore,Dan H. Moore,Gary K. Scott,Michael J. Birrer,Willy Kueng,Urs Eppenberger,Christopher C. Benz,Christopher C. Benz +9 more
TL;DR: Two hypotheses are supported: (i) dysregulated ER expression underlies the age-specific increase in breast cancer incidence after age 50; and (ii) oxidative stress and loss of Sp1 DNA-binding may contribute to an increasing incidence in higher-risk ER-positive/PR-negative breast cancers with aging.
Journal ArticleDOI
Preferential oxidation of zinc finger 2 in estrogen receptor DNA-binding domain prevents dimerization and, hence, DNA binding.
Randy M. Whittal,Christopher C. Benz,Gary K. Scott,Jenia Semyonov,Alma L. Burlingame,Michael A. Baldwin +5 more
TL;DR: Findings indicate that the loss of ER DNA-binding function in extracts from some primary breast tumors and in ER or ER-DBD exposed to thiol-reacting oxidants results from this asymmetric zinc finger susceptibility to disulfide formation that prevents dimerization.