M
Michael A. Baldwin
Researcher at University of California, San Francisco
Publications - 81
Citations - 8542
Michael A. Baldwin is an academic researcher from University of California, San Francisco. The author has contributed to research in topics: Mass spectrometry & Peptide sequence. The author has an hindex of 45, co-authored 81 publications receiving 8365 citations. Previous affiliations of Michael A. Baldwin include Buck Institute for Research on Aging.
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Journal ArticleDOI
Structural studies of the scrapie prion protein using mass spectrometry and amino acid sequencing
Neil Stahl,Michael A. Baldwin,David B. Teplow,Leroy Hood,Bradford W. Gibson,Alma L. Burlingame,Stanley B. Prusiner +6 more
TL;DR: This work contends that PrPSc molecules do not differ from PrPC at the level of an amino acid substitution or a posttranslational chemical modification; however, it cannot eliminate the possibility that a small fraction ofPrPSc is modified by an as yet unidentified posttranslated process or that PrPC carries a modification that is removed in the formation of PrP Sc.
Journal ArticleDOI
The characteristics of peptide collision-induced dissociation using a high-performance MALDI-TOF/TOF tandem mass spectrometer.
Katalin F. Medzihradszky,Jennifer M. Campbell,Michael A. Baldwin,Arnold M. Falick,Peter Juhasz,Marvin L. Vestal,Alma L. Burlingame +6 more
TL;DR: A new matrix-assisted laser desorption/ionization (MALDI) time-of-flight/time- of-flight (TOF/TOF) high-resolution tandem mass spectrometer is described for sequencing peptides.
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The Need for Guidelines in Publication of Peptide and Protein Identification Data Working Group On Publication Guidelines For Peptide And Protein Identification Data
Steven A. Carr,Ruedi Aebersold,Michael A. Baldwin,Al Burlingame,Karl R. Clauser,Alexey I. Nesvizhskii +5 more
TL;DR: In an effort to ensure that high-quality, significant data are entering the proteomics literature, Molecular & Cellular Proteomics (MCP) is introducing guidelines for authors planning to submit manuscripts containing large numbers of proteins identified primarily by LC-MS/MS.
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Pathway complexity of prion protein assembly into amyloid.
TL;DR: To study the kinetic pathways of amyloid formation in vitro, unglycosylated recombinant PrP corresponding to the proteinase K-resistant core of PrPSc is used and it is found that it can adopt two non-native abnormal isoforms, a β-oligomer and anAmyloid fibril.
Journal ArticleDOI
Atmospheric pressure matrix-assisted laser desorption/ionization mass spectrometry.
TL;DR: A novel ionization source for biological mass spectrometry that combines atmospheric pressure (AP) ionization and matrix-assisted laser desorption/ionization (MALDI) and the transfer of the ions from the atmospheric pressure ionization region to the high vacuum is pneumatically assisted (PA) by a stream of nitrogen, hence the acronym PA-AP MALDI.