G
Gary L. Johnson
Researcher at University of North Carolina at Chapel Hill
Publications - 203
Citations - 13361
Gary L. Johnson is an academic researcher from University of North Carolina at Chapel Hill. The author has contributed to research in topics: Kinase & MAP kinase kinase kinase. The author has an hindex of 62, co-authored 196 publications receiving 12436 citations. Previous affiliations of Gary L. Johnson include University of Colorado Denver.
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Journal ArticleDOI
Human neutrophil immunodeficiency syndrome is associated with an inhibitory Rac2 mutation
Daniel R. Ambruso,Cindy Knall,Amy N. Abell,Julie A. Panepinto,Arlet G. Kurkchubasche,Gail Thurman,Carolina Gonzalez-Aller,Andrew A. Hiester,Martin deBoer,Ronald J. Harbeck,Ryan Oyer,Gary L. Johnson,Dirk Roos +12 more
TL;DR: The description of an inhibitory mutation in a member of the Rho family of GTPases associated with a human immunodeficiency syndrome is described.
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MEKKs, GCKs, MLKs, PAKs, TAKs, and tpls: upstream regulators of the c-Jun amino-terminal kinases?
TL;DR: Regulation of the JNK pathway provides an interesting example of how many different stimuli can converge into regulating pathways critical for the determination of cell fate.
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Sequential protein kinase reactions controlling cell growth and differentiation
TL;DR: The identification of Raf-1, a serine-threonine protein kinase in the MAPK pathway, as an effector for Ras GTP was identified, and these discoveries were combined to identify tyrosine kinase receptor regulation of Ras.
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Role of MEKK1 in cell survival and activation of JNK and ERK pathways defined by targeted gene disruption.
TL;DR: Loss of MEKK1 expression resulted in a greater apoptotic response of cells to hyperosmolarity and microtubule disruption, and activated JNK normally in response to heat shock, anisomycin, and ultraviolet irradiation.
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Nuclear protein phosphatase 2A dephosphorylates protein kinase A-phosphorylated CREB and regulates CREB transcriptional stimulation.
Brian E. Wadzinski,W H Wheat,S Jaspers,L F Peruski,R L Lickteig,Gary L. Johnson,Dwight J. Klemm +6 more
TL;DR: The ability of okadaic acid to enhance PKA-stimulated transcription in vitro was entirely dependent on the presence of CREB in the reactions, and Nuclear PP2A appears to be the primary phosphatase that dephosphorylates Pka- phosphorylated CREB.