Gary P. Cofer

TL;DR: In this article, the authors made diffusion coefficient maps of both hyperpolarized (3)He and (129)Xe in guinea pig lungs and found that along the length of the trachea, the average 3)He D values were on average 2.4 cm(2)/sec.

TL;DR: This study shows that 129Xe ADC MRI is clinically feasible, sufficiently sensitive to distinguish HV from subjects with emphysema, and detects age‐ and posture‐dependent changes.

TL;DR: The results suggest that dissolved HP 129Xe imaging reports on pulmonary function at a fundamental level are consistent with gravity-dependent lung deformation, which produces increased ventilation, reduced alveolar size, higher tissue densities, and increased perfusion in the dependent portions of the lungs.

TL;DR: The relaxation behavior was predicted by treating the lung as a porous medium, resulting in good agreement between estimated and measured T∗︁2 values in the intrapulmonary airspaces.

TL;DR: A standardized protocol that allows acquisition of 3D MR histology (43-microm resolution) images of the fixed, stained mouse brain with acquisition times <30 min is described, which yields a searchable database for archive and query of the very large images acquired with this standardized protocol.