S
S. Sivaram Kaushik
Researcher at GE Healthcare
Publications - 28
Citations - 1189
S. Sivaram Kaushik is an academic researcher from GE Healthcare. The author has contributed to research in topics: Breathing & Magnetic resonance imaging. The author has an hindex of 14, co-authored 28 publications receiving 960 citations. Previous affiliations of S. Sivaram Kaushik include Duke University & Medical College of Wisconsin.
Papers
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Journal ArticleDOI
Diffusion-weighted hyperpolarized 129Xe MRI in healthy volunteers and subjects with chronic obstructive pulmonary disease.
S. Sivaram Kaushik,Zackary I. Cleveland,Gary P. Cofer,Gregory Metz,Denise Beaver,John Nouls,Monica Kraft,William F. Auffermann,Jan Wolber,H. Page McAdams,Bastiaan Driehuys +10 more
TL;DR: This study shows that 129Xe ADC MRI is clinically feasible, sufficiently sensitive to distinguish HV from subjects with emphysema, and detects age‐ and posture‐dependent changes.
Journal ArticleDOI
Hyperpolarized 129Xe MR Imaging of Alveolar Gas Uptake in Humans
Zackary I. Cleveland,Gary P. Cofer,Gregory Metz,Denise Beaver,John Nouls,S. Sivaram Kaushik,Monica Kraft,Jan Wolber,Kevin T. Kelly,H. Page McAdams,Bastiaan Driehuys +10 more
TL;DR: The results suggest that dissolved HP 129Xe imaging reports on pulmonary function at a fundamental level are consistent with gravity-dependent lung deformation, which produces increased ventilation, reduced alveolar size, higher tissue densities, and increased perfusion in the dependent portions of the lungs.
Journal ArticleDOI
Chronic Obstructive Pulmonary Disease: Safety and Tolerability of Hyperpolarized 129Xe MR Imaging in Healthy Volunteers and Patients
Bastiaan Driehuys,Santiago Martinez-Jimenez,Zackary I. Cleveland,Gregory Metz,Denise Beaver,John Nouls,S. Sivaram Kaushik,Rafael Firszt,Christine Willis,Kevin T. Kelly,Jan Wolber,Monica Kraft,H. Page McAdams +12 more
TL;DR: Inhalation of hyperpolarized xenon 129 (129)Xe is well tolerated in healthy subjects and in those with mild or moderate COPD, and subjects do experience mild, transient, xenon-related symptoms, consistent with its known anesthetic properties.
Journal ArticleDOI
Single-breath clinical imaging of hyperpolarized (129)Xe in the airspaces, barrier, and red blood cells using an interleaved 3D radial 1-point Dixon acquisition.
S. Sivaram Kaushik,Scott H. Robertson,Matthew S. Freeman,Mu He,Kevin T. Kelly,Justus E. Roos,Craig R. Rackley,W. Michael Foster,H. Page McAdams,Bastiaan Driehuys +9 more
TL;DR: A clinically feasible 1‐point Dixon, three‐dimensional radial acquisition strategy to create isotropic 3D MR images of 129Xe in the airspaces, barrier, and red blood cells (RBCs) in a single breath is developed and tested.
Journal ArticleDOI
Measuring diffusion limitation with a perfusion-limited gas--hyperpolarized 129Xe gas-transfer spectroscopy in patients with idiopathic pulmonary fibrosis.
S. Sivaram Kaushik,Matthew S. Freeman,Suk W. Yoon,Maria Liljeroth,Jane V. Stiles,Justus E. Roos,W. Sivaram Michael Foster,Craig R. Rackley,H P McAdams,Bastiaan Driehuys +9 more
TL;DR: This work hypothesized that in patients with idiopathic pulmonary fibrosis (IPF), the ratio of (129)Xe spectroscopic signal in the RBCs vs. barrier would diminish as diffusion-limitation delayed replenishment of ( 129) Xe magnetization in RBC’s.