Gary V. Martinez

TL;DR: Differential scanning calorimetry and deuterium ((2)H) NMR experiments on acyl chain perdeuterated lipids demonstrate that LL-37 inserts into the hydrophobic region of the bilayer and alters the chain packing and cooperativity, and shows that hydrophobia interactions between LL- 37 and the Hydrophobic acyl chains are as important for the ability of this peptide to disrupt lipid bilayers as its electrostatic interactions with the polar headgroups.

TL;DR: The findings indicate that pharmacologic induction of T-cell chemokine expression represents a conceptually novel approach for enhancing immunotherapy response and suggest that combination of HDAC inhibitors with PD-1 blockade represents a promising strategy for lung cancer treatment.

TL;DR: Different MR methods in measuring tumor pH are discussed along with emphasizing the importance of extracelluar tumor low pH on different steps of metastasis; more specifically focusing on epithelial‐to‐mesenchymal transition (EMT), and anti cancer immunity.

TL;DR: An inverse relationship between pHe and tumor perfusion is revealed and new MRI methods based on pH‐sensitive T1 relaxivity are an attractive alternative to previous spectroscopic methods, as they allow improvements in spatial and temporal resolution.

TL;DR: The composition and temperature dependence of the microstructure indicates that phase separation is driven thermodynamically rather than being a kinetically trapped relic of the shell-formation process, and highlights the nonequilibrium (history-dependent) nature of the monolayer shell.