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Gaurav Datta
Researcher at University of North Dakota
Publications - 18
Citations - 238
Gaurav Datta is an academic researcher from University of North Dakota. The author has contributed to research in topics: Plasmodium falciparum & Hemozoin. The author has an hindex of 8, co-authored 18 publications receiving 159 citations. Previous affiliations of Gaurav Datta include International Centre for Genetic Engineering and Biotechnology.
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Plasmodium falciparum OTU‐like cysteine protease (PfOTU) is essential for apicoplast homeostasis and associates with noncanonical role of Atg8
TL;DR: Functional role of a novel ovarian tumour unit (OTU) domain‐containing cysteine protease of Plasmodium falciparum is identified and it is shown that the PfOTU is involved in apicoplast homeostasis and associates with the noncanonical function of Atg8 in maintenance of parasite apICoplast.
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Role of endolysosomes and pH in the pathogenesis and treatment of glioblastoma.
Peter W. Halcrow,Gaurav Datta,Joyce E. Ohm,Mahmoud L. Soliman,Xuesong Chen,Jonathan D. Geiger +5 more
TL;DR: Glioblastoma multiforme is a Grade IV astrocytoma with an aggressive disease course and a uniformly poor prognosis and the treatment options include a combination of surgical resection, radiotherapy, and chemotherapy with the alkylating agent temozolomide.
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Importance of measuring endolysosome, cytosolic, and extracellular pH in understanding the pathogenesis of and possible treatments for glioblastoma multiforme
TL;DR: The extracellular environment near GBM tumors is acidified and is relevant to the pathogenesis of GBM because decreased pH promotes tumor cell invasion, increases angiogenesis, decreases immune surveillance, and increases resistance to possible treatments.
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Apolipoprotein E isoform dependently affects Tat-mediated HIV-1 LTR transactivation
TL;DR: Findings help explain observed differential effects of ApoEs on HIV-1 infectivity and the prevalence of HAND in people living with HIV- 1 infection and suggest that ApoE mimetic peptides and Apo E4 structure modulator might be used as a therapeutic strategy against HIV-2 infection and associated neurocognitive disorders.
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An essential vesicular-trafficking phospholipase mediates neutral lipid synthesis and contributes to hemozoin formation in Plasmodium falciparum.
Mohd Asad,Yoshiki Yamaryo-Botté,Mohammad E. Hossain,Vandana Thakur,Shaifali Jain,Gaurav Datta,Cyrille Y. Botté,Asif Mohmmed +7 more
TL;DR: In this paper, the authors showed that the transient downregulation of the parasite phospholipase (P. falciparum lysophospholipases, PfLPL1) caused a significant reduction of neutral lipids in the food vacuole-associated lipid bodies, which hindered the conversion of heme, originating from host haemoglobin, into inert hemozoin.