Jonathan D. Geiger

TL;DR: The goal was to use microarray and complementary technologies in adolescent rats to understand the anticonvulsant effect of the ketogenic diet, which typically is used in pediatric epilepsies, but is effective also in adolescents and adults.

TL;DR: It is shown that ketogenic diet can reduce seizures in mice by increasing activation of adenosine A1 receptors (A1Rs) and that adenosines deficiency may be relevant to human epilepsy and that KD can reducing seizures by increasing A1R-mediated inhibition.

TL;DR: The data presented here clearly highlight the complexity of using adenosinergic agents therapeutically in PD and other neurodegenerative disorders and point out many areas for further inquiry, and confirm that adenosine receptor ligands, particularly A2A receptor ligand, have many promising characteristics that encourage the pursuit of their therapeutic potential.

TL;DR: Increased oxidative stress is present in brain and CSF of HIV-infected patients and several novel compounds that are capable of blocking the CSF-induced toxicity are identified, the therapeutic potential of which is worthy of further exploration.

TL;DR: It is shown that sphingomyelin phosphodiesterase 3 (also known as neutral sphingomeelinase‐2) is critical for tumor necrosis factor (TNF) α‐induced trafficking of NMDA receptors and synaptic plasticity.