G
Geen-Dong Chang
Researcher at National Taiwan University
Publications - 74
Citations - 2451
Geen-Dong Chang is an academic researcher from National Taiwan University. The author has contributed to research in topics: Signal transduction & Complementary DNA. The author has an hindex of 26, co-authored 70 publications receiving 2112 citations. Previous affiliations of Geen-Dong Chang include National Yang-Ming University.
Papers
More filters
Journal ArticleDOI
GCMa regulates the syncytin-mediated trophoblastic fusion.
Chenchou Yu,Kuofeng Shen,Mei-Yao Lin,Porchun Chen,Chenchen Lin,Geen-Dong Chang,Hungwen Chen,Hungwen Chen +7 more
TL;DR: GCMa was able to regulatesyncytin gene expression via two GCMa-binding sites upstream of the 5′-long terminal repeat of thesyncytin-harboring HERV-W family member in BeWo and JEG3 cells but not in HeLa cells, which may help to explain the mechanism underlying the cell fusion event specific for syncytiotrophoblast formation.
Journal ArticleDOI
White Spot Syndrome Virus Induces Metabolic Changes Resembling the Warburg Effect in Shrimp Hemocytes in the Early Stage of Infection
I-Tung Chen,Takashi Aoki,Yun-Tzu Huang,Ikuo Hirono,Tsan Chi Chen,Jiun Yan Huang,Geen-Dong Chang,Chu Fang Lo,K.C. Han-Ching Wang +8 more
TL;DR: Evidence that metabolic changes resembling the Warburg effect are induced by a nonmammalian virus is presented and it is shown that double-stranded RNA silencing of the VDAC reduces WSSV-induced mortality and virion copy number.
Journal ArticleDOI
Functional Characterization of the Placental Fusogenic Membrane Protein Syncytin
Chie-Pein Chen,Liang-Fu Chen,Su-Ray Yang,Chia-Yu Chen,Chun-Chuan Ko,Geen-Dong Chang,Hungwen Chen,Hungwen Chen +7 more
TL;DR: The results suggest that syncytin 2 may function as a second fusogenic protein for placental cell fusion, and it is demonstrated that the disulfide bridge-forming CX2C and CX7C motifs found in syncytins 1 and 2 are essential for theirfusogenic activities.
Journal ArticleDOI
An invertebrate Warburg effect: a shrimp virus achieves successful replication by altering the host metabolome via the PI3K-Akt-mTOR pathway.
Mei-An Su,Yun-Tzu Huang,I-Tung Chen,Der-Yen Lee,Yun-Chieh Hsieh,Chun-Yuan Li,Tze Hann Ng,Suh-Yuen Liang,Shu-Yu Lin,Shiao Wei Huang,Chiang Yi-An,Hon-Tsen Yu,Kay-Hooi Khoo,Geen-Dong Chang,Chu Fang Lo,Han Ching Wang +15 more
TL;DR: It is shown that the PI3K-Akt-mTOR pathway was of central importance in triggering this WSSV-induced Warburg effect, which appears to be essential for successful viral replication.
Journal ArticleDOI
Endocytic pathway is required for Drosophila Toll innate immune signaling
TL;DR: It is shown that endocytosis is required for the activation of the Toll signaling pathway and that the Mop protein functions upstream of the MyD88 adaptor and the Pelle kinase.