Showing papers by "Geeta Talukder published in 1990"
TL;DR: Protection against clastogenicity induced by lead (Pb) and aluminium (Al) salts on mouse bone marrow chromosomes may be due to the combined action of all ingredients, rather than to AA alone.
Abstract: Extract of Phyllanthus emblica fruit and ascorbic acid were evaluated separately for protection against clastogenicity induced by lead (Pb) and aluminium (Al) salts on mouse bone marrow chromosomes. Oral administration of Phyllanthus fruit extract (PFE) for 7 days before exposure to both metals by intraperitoneal injection increased the frequency of cell division and reduced the frequency of chromosome breaks significantly. Comparable doses of synthetic ascorbic acid (AA) were less effective and could protect against the effects of Al and only a low dose of Pb (10 mg/kg body weight). AA administered before treatment in mice given higher doses of Pb (40 mg/kg body weight) enhanced the frequency of chromosome breaks, giving a synergistic effect. The higher protection afforded by PFE may be due to the combined action of all ingredients, rather than to AA alone.
65 citations
Journal Article•
TL;DR: The results indicate that tartrazine is more clastogenic than curcumin, and sister chromatid exchanges and chromosomal aberrations induced byCurcumin and Tartrazine following acute and chronic exposure via the diet.
Abstract: Sister chromatid exchanges (SCEs) and chromosomal aberrations induced by curcumin (a natural dye) and tartrazine (a synthetic dye) were studied on bone marrow cells of mice and rats following acute and chronic exposure via the diet. Except for two low concentrations in the curcumin and one low concentration in the tartrazine treated series a significant increase in SCEs was observed in all the concentrations of the two dyes tested. Except for two high concentrations during the 9 months treatment no significant increase in chromosomal aberrations was observed in the curcumin treated series, whereas tartrazine showed a significant increase in chromosomal aberrations in some of the higher concentrations in all the series tested. The results indicate that tartrazine is more clastogenic than curcumin.
59 citations
TL;DR: Copper sulphate administered intraperitoneally to Swiss albino mice in vivo induced a significant increase in the frequency of chromosomal aberrations in bone marrow cells as all concentrations used when compared to the negative control.
59 citations
TL;DR: The progressive increase in the use of aluminium compounds has enhanced the possibility of human exposure and, in spite of its low absorption rate, A1 accumulates in certain tissues, resulting in neurotoxic effects.
34 citations
TL;DR: The clastogenicity of trimethyltin chloride was evaluated in human peripheral blood lymphocytes with micronucleus counts (MNC) as the endpoint and higher frequencies of MNC enhancement were observed in male individuals than in females.
32 citations
TL;DR: The persistence of chromosomal abnormalities in the form of replicating minutes and exchange configurations, even 1114 days after exposure to the gas, may indicate a residual effect on T-cell precursors.
Abstract: Frequencies of chromosomal abnormalities, sister chromatid exchanges, and replicative index were assessed following peripheral lymphocyte culture in 129 individuals from Bhopal, India. Of these, 83 persons (40 male and 43 female) had been exposed directly to the methyl isocyanate (MIC) gas after the accident at the Union Carbide plant on December 2 and 3, 1984. The remaining 46 samples were taken from age-matched unexposed persons in the same city. Chromosome aberrations were recorded at first cycle metaphase (M1) and sister chromatid exchanges, at second cycle metaphase (M2), following standard schedule. The frequency of chromosomal aberrations was, in general, higher in individuals from the exposed populations, with the females showing a higher incidence. Nondisjunction of chromosomes or laggard was rare. The frequencies of sister chromatid exchanges and depression in mitotic and replicative indices could not be related to exposure or sex. The persistence of chromosomal abnormalities in the form of replicating minutes and exchange configurations, even 1114 days after exposure to the gas, may indicate a residual effect on T-cell precursors.
29 citations
TL;DR: Oral administration of aqueous extracts of Phyllanthus emblica L. fruit and P. niruri leaves to laboratory bred albino mice for a week significantly reduced the cytotoxic action of lead nitrate and aluminium sulphate.
Abstract: Oral administration of aqueous extracts of Phyllanthus emblica L. fruit and P. niruri L. leaves to laboratory bred albino mice for a week, significantly reduced the cytotoxic action of lead nitrate and aluminium sulphate. The frequency of chromosomal breakages, gaps and rearrangements induced by three concentrations of these salts was decreased when compared to the control animals which had received the salts alone. The plant extracts were equally effective in modifying the clastogenic effects of both lead nitrate and aluminium sulphate.
22 citations
TL;DR: The incidence of chromosome aberrations increased linearly with increasing concentrations of the chemical from 1/20th to 1/5th of the LD50, and the frequency of cell division was enhanced by the lower doses but higher doses were mitostatic.
14 citations
TL;DR: This is the first report on the clastogenicity of zirconium oxychloride, and female mice were found to be more susceptible than male mice, though not to a significantly higher level.
14 citations
TL;DR: Oral administration of different concentrations of Strontium chloride to laboratory bred mice in vivo induced chromosomal aberrations in bone marrow cell metaphase preparations resulted in clastogenicity and females showed greater susceptibility than the males at all concentrations used.
Abstract: Oral administration of different concentrations of Strontium chloride to laboratory bred mice in vivo induced chromosomal aberrations in bone marrow cell metaphase preparations. The degree of clastogenicity was directly proportional to concentration used at 6, 12, and 24 h of treatment. Duration of treatment could only be related positively in the lower doses. The females showed greater susceptibility than the males at all concentrations used.
9 citations
Journal Article•
TL;DR: Oral administration of calcium, following by aluminium or together with Al, has been found to counteract the toxic effects of the latter metal as observed in histological preparations of liver, brain, kidney, and bone of laboratory albino rats.
Abstract: Oral administration of calcium, following by aluminium or together with Al, has been found to counteract the toxic effects of the latter metal as observed in histological preparations of liver, brain, kidney, and bone of laboratory albino rats. No such improvement was seen if Ca was administered after Al. The protection afforded by Ca against Al toxicity may be due to the previous occupation by Ca ions of the binding sites of Al ions in the affected organs.
TL;DR: The Histopathological Effect Of Chewing Of Betel Quid Without Tobacco Was Studied By Simulating 14 Different Chewing Habits Using The Mouse Glandular Stomach Mucosa As A Model Mammalian System to Find Out Whether These Changes Were Erosions and Regenerative Hyperplasia Of The Pyloric Glands.
Abstract: The Histopathological Effect Of Chewing Of Betel Quid Without Tobacco Was Studied By Simulating 14 Different Chewing Habits Using The Mouse Glandular Stomach Mucosa As A Model Mammalian System. Chronic Oral Administration For 8 To 10 Months Resulted In Marked Architectural Atypia In Animals Receiving Extracts Of Areca Catechu L. Red Nut, With Piper Betle L. Varieties and A Combination Of Nut, Leaf and Lime. The Initial Histologic Changes Were Erosions and Regenerative Hyperplasia Of The Pyloric Glands. After Atrophy and Erosion Of The Mucosa, Regenerative Glandular Hyperplasia Developed In Animals Receiving Lime Suspension While Marked Adenomatous Hyperplasia Exhibiting Excessive Glandular Proliferation, Often With Peripheral Growth Into The Stomach Cavity, With Few Cellular Atypism Developed In Animals Receiving Combinations Of P. Betle Var. Bangla, A. Catechu and Low Concentration Of Lime (B Bn Lmn) and A. Catechu With Low Concentration Of Lime (Cbn Lmn). High Dose Of Lime Together With P. Betle...
TL;DR: Cytotoxic effects of Al, measured by the induction of chromosomal aberrations, were countered by treatment with Ca and protection afforded was maximum when Ca was fed at a ratio of 3:1, as related to Al, 2 hours before the administration of Al.
Abstract: The interaction of Al with Ca in six different combinations was studied in bone marrow chromosomes following daily oral administration for prolonged periods. Cytotoxic effects of Al, measured by the induction of chromosomal aberrations, were countered by treatment with Ca. The protection afforded was maximum when Ca was fed at a ratio of 3:1, as related to Al, 2 hours before the administration of Al.