G
Gemma L. Clayton
Researcher at University of Bristol
Publications - 32
Citations - 571
Gemma L. Clayton is an academic researcher from University of Bristol. The author has contributed to research in topics: Medicine & Internal medicine. The author has an hindex of 8, co-authored 18 publications receiving 335 citations. Previous affiliations of Gemma L. Clayton include Bristol Royal Infirmary.
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Journal ArticleDOI
Empirical Evidence of Study Design Biases in Randomized Trials: Systematic Review of Meta-Epidemiological Studies.
Matthew J. Page,Julian P T Higgins,Gemma L. Clayton,Jonathan A C Sterne,Asbjørn Hróbjartsson,Jelena Savović,Jelena Savović +6 more
TL;DR: The available evidence suggests that intervention effect estimates may be exaggerated in trials with inadequate/unclear (versus adequate) sequence generation and allocation concealment, and the average bias appears to be greatest in trials of subjective outcomes.
Journal ArticleDOI
Impact of blinding on estimated treatment effects in randomised clinical trials: meta-epidemiological study.
Helene Moustgaard,Helene Moustgaard,Gemma L. Clayton,Hayley E Jones,Isabelle Boutron,Lars N. Jorgensen,David Ruben Teindl Laursen,David Ruben Teindl Laursen,Mette F Olsen,Asger Sand Paludan-Müller,Philippe Ravaud,Jelena Savović,Jelena Savović,Jonathan A C Sterne,Jonathan A C Sterne,Julian P T Higgins,Julian P T Higgins,Asbjørn Hróbjartsson,Asbjørn Hróbjartsson +18 more
TL;DR: No evidence was found for an average difference in estimated treatment effect between trials with and without blinded patients, healthcare providers, or outcome assessors, and this results could reflect that blinding is less important than often believed or meta-epidemiological study limitations, such as residual confounding or imprecision.
Journal ArticleDOI
Randomized trial of near-infrared spectroscopy for personalized optimization of cerebral tissue oxygenation during cardiac surgery.
Chris A Rogers,Serban Stoica,Lucy Ellis,Elizabeth A Stokes,Sarah Wordsworth,L. Dabner,Gemma L. Clayton,R. Downes,E. Nicholson,S. Bennett,Gianni D Angelini,Barnaby C Reeves,Gavin J. Murphy +12 more
TL;DR: These results do not support the use of NIRS-based algorithms for the personalized optimization of cerebral oxygenation in adult cardiac surgery.
Journal ArticleDOI
Ethnic discordance in serum anti-Müllerian hormone in healthy women: a population study from China and Europe.
Scott M. Nelson,Sun Aijun,Qui Ling,Xu Tengda,Xue Wei,Deng Yan,Wang Yanfang,Tian Zenghui,Chen Xinqi,Abigail Fraser,Gemma L. Clayton +10 more
TL;DR: There were independent effects of age and ethnicity on serum AMH concentrations, with Chinese women having a substantially lower AMH in adult life than their European counterparts from age 25 onwards.
Journal ArticleDOI
Bias from questionnaire invitation and response in COVID-19 research: an example using ALSPAC
Alba Fernández-Sanlés,Daniel J. Smith,Gemma L. Clayton,Kate Northstone,Alice R Carter,Louise A C Millard,Maria Carolina Borges,Nicholas J. Timpson,Kate Tilling,Gareth J Griffith,Debbie A Lawlor +10 more
TL;DR: Ass associations of pre-pandemic sociodemographic, behavioural, anthropometric and health-related factors with questionnaire invitation and response in COVID-19 questionnaire data collection in a multigenerational birth cohort are assessed.