Gemma Pascual

TL;DR: Results indicate that MMP-2 may be involved in the TF matrix degradative process in patients with direct hernia, suggesting a genetic defect or irreversible change as the origin of this pathology rather than environmental factors, which may later participate in the development of the hernial process.

TL;DR: Finite element simulation of the healthy and partially herniated repaired rabbit abdominal wall served to reproduce wall behaviour before and after mesh implant, and the Infinit® mesh was able to best comply with the biomechanics of the abdominal wall.

TL;DR: In this article, the anterior abdominal wall of New Zealand white rabbits was repaired by using a nonabsorbable polypropylene prosthesis (Surgipro; Tyco, Barcelona, Spain) or 1 of 2 partially absorbable prostheses available on the market (Vypro II and Ultrapro; Johnson & Johnson, St. Stevens-Woluwe, Belgium).

TL;DR: Assessment of the early host tissue incorporation of several polypropylene lightweight meshes used to repair abdominal wall defects showed excellent incorporation in host tissue, and Optilene, the most porous LW mesh examined, showed the greatest tensile strength 14 days after implant.

TL;DR: The CAs promoted proper mesh fixation and have potential to replace traditional suturing techniques in hernia repair; the CAs exhibited good tissue integration and effective short-term biocompatibility, with the slightest seroma and macrophage response induced by OCA.