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Gemma R Brett
Researcher at University of Melbourne
Publications - 16
Citations - 1040
Gemma R Brett is an academic researcher from University of Melbourne. The author has contributed to research in topics: Genetic testing & Cost effectiveness. The author has an hindex of 8, co-authored 13 publications receiving 678 citations. Previous affiliations of Gemma R Brett include Royal Children's Hospital.
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Journal ArticleDOI
A prospective evaluation of whole-exome sequencing as a first-tier molecular test in infants with suspected monogenic disorders
Zornitza Stark,Tiong Yang Tan,Belinda Chong,Gemma R Brett,Patrick Yap,Maie Walsh,Alison Yeung,Heidi Peters,Heidi Peters,Dylan A. Mordaunt,Dylan A. Mordaunt,Shannon Cowie,David J. Amor,Ravi Savarirayan,George McGillivray,Lilian Downie,Paul G Ekert,Christiane Theda,Christiane Theda,Paul A. James,Joy Yaplito-Lee,Monique M. Ryan,Monique M. Ryan,Richard J. Leventer,Richard J. Leventer,Emma Creed,Ivan Macciocca,Katrina M. Bell,Alicia Oshlack,Simon Sadedin,Peter Georgeson,Charlotte Anderson,Natalie P. Thorne,Clara Gaff,Susan M. White +34 more
TL;DR: Singleton WES outperformed standard care in terms of diagnosis rate and the benefits of a diagnosis, namely, impact on management of the child and clarification of reproductive risks for the extended family in a timely manner.
Journal ArticleDOI
Diagnostic Impact and Cost-effectiveness of Whole-Exome Sequencing for Ambulant Children With Suspected Monogenic Conditions
Tiong Yang Tan,Oliver James Dillon,Zornitza Stark,Deborah Schofield,Deborah Schofield,Khurshid Alam,Rupendra N. Shrestha,Belinda Chong,Dean Phelan,Gemma R Brett,Emma Creed,Anna Jarmolowicz,Patrick Yap,Maie Walsh,Lilian Downie,David J. Amor,Ravi Savarirayan,George McGillivray,Alison Yeung,Heidi Peters,Heidi Peters,Susan J. Robertson,Aaron J. Robinson,Ivan Macciocca,Simon Sadedin,Katrina M. Bell,Alicia Oshlack,Peter Georgeson,Natalie P. Thorne,Clara Gaff,Clara Gaff,Susan M. White +31 more
TL;DR: Singleton WES in children with suspected monogenic conditions has high diagnostic yield, and cost-effectiveness is maximized by early application in the diagnostic pathway, compared with the standard diagnostic pathway.
Journal ArticleDOI
Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system
Sebastian Lunke,Stefanie Eggers,Meredith Wilson,Chirag Patel,Christopher P. Barnett,Jason Pinner,Sarah A. Sandaradura,Michael Buckley,Emma I. Krzesinski,Michelle G. de Silva,Gemma R Brett,Kirsten Boggs,David Mowat,Edwin P. Kirk,Edwin P. Kirk,Lesley C. Adès,Lauren S. Akesson,David J. Amor,David J. Amor,Samantha Ayres,Anne Baxendale,Sarah Borrie,Alessandra Bray,Natasha J Brown,Cheng Yee Chan,Cheng Yee Chan,Belinda Chong,Corrina Cliffe,Martin B. Delatycki,Matthew S. Edwards,George Elakis,Michael C Fahey,Andrew Fennell,Lindsay F. Fowles,Lyndon Gallacher,Megan Higgins,Megan Higgins,Katherine B. Howell,Katherine B. Howell,Lauren Hunt,Lauren Hunt,Matthew F. Hunter,Kristi J. Jones,Sarah R. B. King,Smitha Kumble,Sarah Lang,Maelle Le Moing,Alan Ma,Dean Phelan,Michael C.J. Quinn,Anna E. Richards,Christopher M. Richmond,Jessica R. Riseley,Jonathan Rodgers,Rani Sachdev,Simon Sadedin,Luregn J. Schlapbach,Janine Smith,Amanda Springer,Natalie B Tan,Tiong Yang Tan,Suzanna L. Temple,Christiane Theda,Christiane Theda,Anand Vasudevan,Susan M. White,Alison Yeung,Ying Zhu,Melissa Martyn,Stephanie Best,Tony Roscioli,Tony Roscioli,John Christodoulou,Zornitza Stark +73 more
TL;DR: This study suggests feasibility of ultra-rapid genomic testing in critically ill pediatric patients with suspected monogenic conditions in the Australian public health care system, however, further research is needed to understand the clinical value of such testing, and the generalizability of the findings to other health care settings.
Journal ArticleDOI
Meeting the challenges of implementing rapid genomic testing in acute pediatric care.
Zornitza Stark,Sebastian Lunke,Gemma R Brett,Natalie B Tan,Rachel Stapleton,S Kumble,Alison Yeung,Dean Phelan,Belinda Chong,Miriam Fanjul-Fernández,Justine E. Marum,Matthew F. Hunter,Matthew F. Hunter,Anna Jarmolowicz,Yael Prawer,Jessica R. Riseley,Matthew Regan,Justine Elliott,Melissa Martyn,Stephanie Best,Tiong Yang Tan,Clara Gaff,Susan M. White +22 more
TL;DR: Rapid genomic testing in acute pediatrics is not only feasible but also cost-effective, and has high diagnostic and clinical utility, and requires a whole-of-system approach for successful implementation.
Journal ArticleDOI
An exploration of genetic health professionals' experience with direct-to-consumer genetic testing in their clinical practice
Gemma R Brett,Sylvia A Metcalfe,Sylvia A Metcalfe,David J. Amor,David J. Amor,Jane Halliday,Jane Halliday +6 more
TL;DR: Direct-to-consumer genetic testing is not a major reason for referral to clinical genetics services in Australia and New Zealand and the majority of genetic health professionals lack confidence in being able to accurately interpret and explain DTC-GT results.