L
Lauren S. Akesson
Researcher at University of Melbourne
Publications - 8
Citations - 236
Lauren S. Akesson is an academic researcher from University of Melbourne. The author has contributed to research in topics: Exome sequencing & Intensive care. The author has an hindex of 5, co-authored 7 publications receiving 100 citations. Previous affiliations of Lauren S. Akesson include Royal Melbourne Hospital & Monash Medical Centre.
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Journal ArticleDOI
Feasibility of ultra-rapid exome sequencing in critically ill infants and children with suspected monogenic conditions in the Australian public health care system
Sebastian Lunke,Stefanie Eggers,Meredith Wilson,Chirag Patel,Christopher P. Barnett,Jason Pinner,Sarah A. Sandaradura,Michael Buckley,Emma I. Krzesinski,Michelle G. de Silva,Gemma R Brett,Kirsten Boggs,David Mowat,Edwin P. Kirk,Edwin P. Kirk,Lesley C. Adès,Lauren S. Akesson,David J. Amor,David J. Amor,Samantha Ayres,Anne Baxendale,Sarah Borrie,Alessandra Bray,Natasha J Brown,Cheng Yee Chan,Cheng Yee Chan,Belinda Chong,Corrina Cliffe,Martin B. Delatycki,Matthew S. Edwards,George Elakis,Michael C Fahey,Andrew Fennell,Lindsay F. Fowles,Lyndon Gallacher,Megan Higgins,Megan Higgins,Katherine B. Howell,Katherine B. Howell,Lauren Hunt,Lauren Hunt,Matthew F. Hunter,Kristi J. Jones,Sarah R. B. King,Smitha Kumble,Sarah Lang,Maelle Le Moing,Alan Ma,Dean Phelan,Michael C.J. Quinn,Anna E. Richards,Christopher M. Richmond,Jessica R. Riseley,Jonathan Rodgers,Rani Sachdev,Simon Sadedin,Luregn J. Schlapbach,Janine Smith,Amanda Springer,Natalie B Tan,Tiong Yang Tan,Suzanna L. Temple,Christiane Theda,Christiane Theda,Anand Vasudevan,Susan M. White,Alison Yeung,Ying Zhu,Melissa Martyn,Stephanie Best,Tony Roscioli,Tony Roscioli,John Christodoulou,Zornitza Stark +73 more
TL;DR: This study suggests feasibility of ultra-rapid genomic testing in critically ill pediatric patients with suspected monogenic conditions in the Australian public health care system, however, further research is needed to understand the clinical value of such testing, and the generalizability of the findings to other health care settings.
Journal ArticleDOI
Aspergillus Infections and Progression of Structural Lung Disease in Children with Cystic Fibrosis.
Oded Breuer,Oded Breuer,André Schultz,André Schultz,Luke W. Garratt,Lidija Turkovic,Tim Rosenow,Tim Rosenow,Conor P Murray,Yuliya V. Karpievitch,Lauren S. Akesson,Lauren S. Akesson,Samuel Dalton,Peter D. Sly,Sarath Ranganathan,Sarath Ranganathan,Stephen M. Stick,Stephen M. Stick,Daan Caudri,Daan Caudri +19 more
TL;DR: Lower respiratory Aspergillus infections are associated with the progression of structural lung disease in young children with CF and the need to further evaluate early AsperGillus species infections and the feasibility, risk and benefit of eradication regimens is highlighted.
Journal ArticleDOI
The clinical significance of oropharyngeal cultures in young children with cystic fibrosis.
Oded Breuer,Oded Breuer,Daan Caudri,Lauren S. Akesson,Lauren S. Akesson,Lauren S. Akesson,Sarath Ranganathan,Stephen M. Stick,Stephen M. Stick,André Schultz,André Schultz +10 more
TL;DR: Oropharyngeal swab cultures in children with CF are not helpful for ruling out lower airway Pseudomonas infection and are not associated with structural lung disease, lung inflammation or admissions for respiratory exacerbations.
Journal ArticleDOI
Early diagnosis of Pearson syndrome in neonatal intensive care following rapid mitochondrial genome sequencing in tandem with exome sequencing
Lauren S. Akesson,Stefanie Eggers,Clare J. Love,Belinda Chong,Emma I. Krzesinski,Natasha J Brown,Tiong Yang Tan,Christopher M. Richmond,David R. Thorburn,John Christodoulou,Matthew F. Hunter,Matthew F. Hunter,Sebastian Lunke,Zornitza Stark +13 more
TL;DR: Mitochondrial genome sequencing identified a large mtDNA deletion in both infants, diagnosing Pearson syndrome within 74 and 55 h, respectively, and should be considered as an adjunct to exome sequencing in rapid genomic diagnosis programmes.
Journal ArticleDOI
Rapid exome sequencing and adjunct RNA studies confirm the pathogenicity of a novel homozygous ASNS splicing variant in a critically ill neonate.
Lauren S. Akesson,Lauren S. Akesson,Adam Bournazos,Adam Bournazos,Andrew Fennell,Andrew Fennell,Emma I. Krzesinski,Emma I. Krzesinski,Kenneth Tan,Kenneth Tan,Amanda Springer,Amanda Springer,Katherine Rose,Katherine Rose,Ilias Goranitis,David S. Francis,Crystle Lee,Fathimath Faiz,Mark R. Davis,John Christodoulou,Sebastian Lunke,Zornitza Stark,Matthew F. Hunter,Matthew F. Hunter,Sandra T. Cooper,Sandra T. Cooper,Sandra T. Cooper +26 more
TL;DR: The diagnostic benefits of adjunct RNA testing are highlighted to confirm the pathogenicity of splicing variants identified via rapid genomic testing pipelines for precision and preventative medicine.