P
Paul G Ekert
Researcher at Peter MacCallum Cancer Centre
Publications - 158
Citations - 12241
Paul G Ekert is an academic researcher from Peter MacCallum Cancer Centre. The author has contributed to research in topics: Apoptosis & Programmed cell death. The author has an hindex of 46, co-authored 138 publications receiving 10708 citations. Previous affiliations of Paul G Ekert include Walter and Eliza Hall Institute of Medical Research & University of Toronto.
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Journal ArticleDOI
Identification of DIABLO, a Mammalian Protein that Promotes Apoptosis by Binding to and Antagonizing IAP Proteins
Anne M. Verhagen,Paul G Ekert,Paul G Ekert,Miha Pakusch,John Silke,Lisa M. Connolly,Gavin E. Reid,Robert L. Moritz,Richard J. Simpson,David L. Vaux +9 more
TL;DR: DIABLO (direct IAP binding protein with low pI) is a novel protein that can bind MIHA and can also interact with MIHB and MIHC and the baculoviral IAP, OpIAP.
Journal ArticleDOI
Programmed Anuclear Cell Death Delimits Platelet Life Span
Kylie D. Mason,Marina R. Carpinelli,Jamie I. Fletcher,Janelle E. Collinge,Adrienne A. Hilton,Sarah Ellis,Priscilla N. Kelly,Paul G Ekert,Donald Metcalf,Andrew W. Roberts,David C.S. Huang,Benjamin T. Kile,Benjamin T. Kile +12 more
TL;DR: It is shown that an intrinsic program for apoptosis controls platelet survival and dictates their life span, and this represents an important paradigm for cellular homeostasis, and has profound implications for the diagnosis and treatment of disorders that affect platelet number and function.
Journal ArticleDOI
HtrA2 promotes cell death through its serine protease activity and its ability to antagonize inhibitor of apoptosis proteins.
Anne M. Verhagen,John Silke,Paul G Ekert,Paul G Ekert,Miha Pakusch,Hitto Kaufmann,Lisa M. Connolly,Catherine L. Day,Anjali Tikoo,Richard Burke,Carolyn Wrobel,Robert L. Moritz,Richard J. Simpson,David L. Vaux +13 more
TL;DR: HtrA2 can, like DIABLO/Smac, prevent XIAP inhibition of active caspase 3in vitro and is able to counteract XIAP protection of mammalian NT2 cells against UV-induced cell death.
Journal ArticleDOI
Apoptosis initiated by Bcl-2-regulated caspase activation independently of the cytochrome c/Apaf-1/caspase-9 apoptosome
Vanessa S. Marsden,Liam O'Connor,Liam O'Connor,Lorraine A. O'Reilly,John Silke,Donald Metcalf,Paul G Ekert,David C.S. Huang,Francesco Cecconi,Keisuke Kuida,Kevin J. Tomaselli,Sophie Roy,Donald W. Nicholson,David L. Vaux,Philippe Bouillet,Jerry M. Adams,Andreas Strasser +16 more
TL;DR: It is concluded that Bcl-2 regulates a caspase activation programme independently of the cytochrome c/Apaf-1/caspase-9 ‘apoptosome’, which seems to amplify rather than initiate the casp enzyme cascade.
Journal ArticleDOI
Heritable GATA2 mutations associated with familial myelodysplastic syndrome and acute myeloid leukemia
Christopher N. Hahn,Christopher N. Hahn,Chan-Eng Chong,Chan-Eng Chong,Catherine Carmichael,Ella J Wilkins,Ella J Wilkins,Peter J. Brautigan,Xiaochun Li,Milena Babic,Ming-Chih Lin,Amandine Carmagnac,Young Koung Lee,Chung H. Kok,Lucia Gagliardi,Kathryn Friend,Paul G Ekert,Carolyn M. Butcher,Anna L. Brown,Ian D. Lewis,Ian D. Lewis,L. Bik To,L. Bik To,Andrew E. Timms,Jan Storek,Sarah Moore,Meryl Altree,Robert Escher,Robert Escher,Peter Bardy,Graeme Suthers,Graeme Suthers,Richard J D'Andrea,Richard J D'Andrea,Marshall S. Horwitz,Hamish S. Scott +35 more
TL;DR: The discovery of GATA2 as a new myelodysplastic syndrome (MDS)-acute myeloid leukemia (AML) predisposition gene is reported and differential effects of the mutations on the transactivation of target genes, cellular differentiation, apoptosis and global gene expression are shown.