G
Geneva Ruth Davis
Researcher at Salk Institute for Biological Studies
Publications - 17
Citations - 792
Geneva Ruth Davis is an academic researcher from Salk Institute for Biological Studies. The author has contributed to research in topics: Pichia pastoris & Yeast. The author has an hindex of 8, co-authored 17 publications receiving 781 citations.
Papers
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Journal ArticleDOI
High–Level Expression and Efficient Assembly of Hepatitis B Surface Antigen in the Methylotrophic Yeast, Pichia Pastoris
James M. Cregg,Juerg Friedrich Tschopp,Cathy A. Stillman,Robert Steven Siegel,M. Akong,William Scot Craig,Richard Gordon Buckholz,Knut Madden,P. A. Kellaris,Geneva Ruth Davis,B. L. Smiley,J. Cruze,R. Torregrossa,G. Velic ecedil,lebi,Gregory Patrick Thill +15 more
TL;DR: The methylotrophic industrial yeast, Pi–chia pastoris, has been developed as a host system for the large–scale production of heterologous proteins, and the synthesis of hepatitis B surface antigen (HBsAg) is described.
Journal ArticleDOI
Structural comparison of the Pichia pastoris alcohol oxidase genes
Patricia J Koutz,Geneva Ruth Davis,Cathy A. Stillman,Kevin J. Barringer,James M. Cregg,Gregory Patrick Thill +5 more
TL;DR: Although alcohol oxidase is found in peroxisomes of P. pastoris, the AOX amino acid sequences did not contain a peptide sequence similar to the peroxISomal transport sequence found at the C‐terminus of somePeroxisomally located proteins in higher eukaryotes.
Patent
Production of insulin-like growth factor-1 in methylotrophic yeast cells
Russell Arthur Brierley,Geneva Ruth Davis,Gregory Clyde Holtz,Martin A. Gleeson,Bradley Drake Howard +4 more
TL;DR: In this article, the authors used recombinant methylotrophic yeast strains for the expression and secretion of insulin-like growth factor-1 (IGF-1), a naturally occurring, relatively short, single chain polypeptide.
Patent
Mixed feed recombinant yeast fermentation
Russell Arthur Brierley,Robert Steven Siegel,Christopher Michael Bussineau,William Scot Craig,Gregory Clyde Holtz,Geneva Ruth Davis,Richard Gordon Buckholz,Gregory Patrick Thill,Lillian Margaret Wondrack,Mary Ellen Digan,Michael M. Harpold,Stephen Vernon Lair,Steven B. Ellis,Mark E. Williams +13 more
TL;DR: In this paper, a method of increasing the production of a recombinant gene product from a culture of recombinant methylotrophic yeast host, wherein said product is made by expression from a recombinative gene sequence operably associated with a methanol-responsive expression control element was proposed.