Genny Orso

TL;DR: It is demonstrated that Atlastin mediates membrane tethering and fusion and strongly suggest that it is the GTPase activity that is required for ER homotypic fusion, which is shown to depend on GTP hydrolysis.

TL;DR: In vivo data strongly support previous reports, providing a probable cause for the neuronal dysfunction in spastin-linked HSP disease and suggests therapeutic targets for HSP treatment and may provide insight into neurological disorders linked to microtubule dysfunction.

TL;DR: It is demonstrated that loss of spastin function elicits HSP-like phenotypes in Drosophila, novel insights into the molecular mechanism of spASTin mutations are provided, and the possibility that therapy with Vinca alkaloids may be efficacious in spastIn-associated HSP and other disorders related to microtubule dysfunction is raised.

TL;DR: This work characterized the role of metabolic transformation in cisplatin resistance and found that C13 cells not only present an increased glucose-uptake and consumption, but also exhibit increased expression and enzymatic activity of the Pentose Phosphate pathway (PPP) enzyme Glucose-6-Phosphate Dehydrogenase (G6PDH).

TL;DR: Positive correlation of the antioxidant activity with the mechanism involved in the physiologic maintenance of the integrity and function of the intestinal epithelium is shown, supporting its use as safe adjuvant in patients affected by IBD.