Geon Hee Kim

TL;DR: It is demonstrated that emodin significantly improved the anti-cancer effect of sorafenib in HCC cells, such as HepG2, Hep3B, Huh7, SK-HEP-1, and PLC/PRF5, and it is suggested that the combination of emod in and sorafENib may offer a potential therapy for patients with advanced HCC.

TL;DR: TQ was found to be a novel HIF-1α inhibitor through hypoxia response element (HRE)-luciferase assay-based large screening by using 502 natural compounds containing chemical library, and it was suggested that TQ is a potential anticancer agent targeting Hif-1 α.

TL;DR: It is suggested that UA is a promising cholesterol-lowering nutraceutical for the prevention and treatment of patients with HCC and cholesterol-related chronic diseases.

TL;DR: It is demonstrated that the activation of RAS-MAPK signaling through the overexpression of H-RasV12 increased HSF1 expression and the cholesterol biosynthesis pathway, and is a potential target for statin-based HCC treatment.

TL;DR: It is suggested that cinobufagin is a potential anti-melanoma drug that suppresses tumor-promoting Wnt/β-catenin signaling via LEF1 inhibition via luciferase assay-based high throughput screening with a natural compound library.