George G. Harrigan

TL;DR: In this postgenomic era, there is a specific need to assign function to orphan genes in order to validate potential targets for drug therapy and to discover new biomarkers of disease.

TL;DR: This review discusses the isolation of dolastatins and close structural analogues from cyanobacteria and some more complex ecology involving movement of cyanobacterial metabolites through the marine food web is presented.

TL;DR: Results from this pilot study indicate high-throughput Fourier-transform infrared spectroscopy could be extended to routine applications in toxicology and to supporting characterization of a new animal model for idiosyncratic susceptibility.

TL;DR: It is concluded that the entry of acetyl Co-A derived from long-chain fatty acid β-oxidation into the mitochondria is facilitated by the mitoNEET ligand PNU-91325, which increases glucose-derived long chain fatty acid synthesis and breakdown via β-Oxidation and anaplerosis in the mitochondaria.

TL;DR: An overview of the rapidly developing field of "metabolic profiling" is presented, which includes the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-gamma agonists, applications of Fourier-transform MS and theUse of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.