D
Daniel J. Brackett
Researcher at University of Oklahoma Health Sciences Center
Publications - 137
Citations - 6407
Daniel J. Brackett is an academic researcher from University of Oklahoma Health Sciences Center. The author has contributed to research in topics: Cancer & Pancreatic cancer. The author has an hindex of 38, co-authored 137 publications receiving 6141 citations. Previous affiliations of Daniel J. Brackett include National Institutes of Health & United States Department of Veterans Affairs.
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Journal ArticleDOI
Expression profiling identifies microRNA signature in pancreatic cancer
Eun Joo Lee,Yuriy Gusev,Jinmai Jiang,Gerard J. Nuovo,Megan R. Lerner,Megan R. Lerner,Wendy L. Frankel,Daniel L. Morgan,Russell G. Postier,Daniel J. Brackett,Daniel J. Brackett,Thomas D. Schmittgen +11 more
TL;DR: A microRNA expression signature has been identified that is associated with pancreatic cancer and Aberrant microRNAs may offer new clues to pancreatic tumorigenesis and may provide diagnostic biomarkers for pancreatic adenocarcinoma.
Journal ArticleDOI
Association of MicroRNA Expression in Hepatocellular Carcinomas with Hepatitis Infection, Cirrhosis, and Patient Survival
Jinmai Jiang,Yuriy Gusev,Yuriy Gusev,Ileana Aderca,Teresa A. Mettler,David M. Nagorney,Daniel J. Brackett,Daniel J. Brackett,Lewis R. Roberts,Thomas D. Schmittgen +9 more
TL;DR: It is shown that a global increase in the transcription of miRNA genes occurs in cirrhotic and hepatitis-positive livers and that miRNA expression may prognosticate disease outcome in HCC.
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Systematic evaluation of microRNA processing patterns in tissues, cell lines, and tumors.
Eun Joo Lee,Myungwon Baek,Yuriy Gusev,Daniel J. Brackett,Gerard J. Nuovo,Thomas D. Schmittgen +5 more
TL;DR: The data demonstrate that a large number of miRNAs are transcribed but are not processed to the mature miRNA, and in situ hybridization analysis demonstrates that these miRNA precursors are retained in the nucleus.
Journal ArticleDOI
Mesothelin Is Overexpressed in Pancreaticobiliary Adenocarcinomas but Not in Normal Pancreas and Chronic Pancreatitis
Raffit Hassan,Zoltan Laszik,Megan R. Lerner,Megan R. Lerner,Mark Raffeld,Russell G. Postier,Daniel J. Brackett,Daniel J. Brackett +7 more
TL;DR: The results demonstrated mesothelin expression in the majority of pancreaticobiliary adenocarcinomas and no expression in normal pancreatic tissues and in chronic pancreatitis.
Journal ArticleDOI
DCAMKL-1 regulates epithelial-mesenchymal transition in human pancreatic cells through a miR-200a-dependent mechanism
Sripathi M. Sureban,Randal May,Stan Lightfoot,Aimee B. Hoskins,Megan R. Lerner,Daniel J. Brackett,Russell G. Postier,Rama P. Ramanujam,Altaf Mohammed,Chinthalapally V. Rao,James H. Wyche,Shrikant Anant,Courtney W. Houchen +12 more
TL;DR: Increased expression of the putative pancreatic stem cell marker DCAMKL-1 is reported in an established KRAS transgenic mouse model of pancreatic cancer and in human pancreatic adenocarcinoma, and a functional role is demonstrated for DCAMC-1 in Pancreatic cancer.