G
George G. Harrigan
Researcher at Pharmacia
Publications - 12
Citations - 1678
George G. Harrigan is an academic researcher from Pharmacia. The author has contributed to research in topics: Fourier transform & Metabolome. The author has an hindex of 11, co-authored 12 publications receiving 1593 citations. Previous affiliations of George G. Harrigan include Pfizer.
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Journal ArticleDOI
Metabolomics by numbers: acquiring and understanding global metabolite data.
Royston Goodacre,Seetharaman Vaidyanathan,Warwick B. Dunn,George G. Harrigan,Douglas B. Kell +4 more
TL;DR: In this postgenomic era, there is a specific need to assign function to orphan genes in order to validate potential targets for drug therapy and to discover new biomarkers of disease.
Journal ArticleDOI
The Cyanobacterial Origin of Potent Anticancer Agents Originally Isolated from Sea Hares
TL;DR: This review discusses the isolation of dolastatins and close structural analogues from cyanobacteria and some more complex ecology involving movement of cyanobacterial metabolites through the marine food web is presented.
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Application of high-throughput Fourier-transform infrared spectroscopy in toxicology studies: contribution to a study on the development of an animal model for idiosyncratic toxicity.
George G. Harrigan,Roxanne H LaPlante,Greg N Cosma,Gary L. Cockerell,Royston Goodacre,Jane F. Maddox,James P. Luyendyk,Patricia E. Ganey,Robert A. Roth +8 more
TL;DR: Results from this pilot study indicate high-throughput Fourier-transform infrared spectroscopy could be extended to routine applications in toxicology and to supporting characterization of a new animal model for idiosyncratic susceptibility.
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PNU-91325 increases fatty acid synthesis from glucose and mitochondrial long chain fatty acid degradation: a comparative tracer-based metabolomics study with rosiglitazone and pioglitazone in HepG2 cells.
TL;DR: It is concluded that the entry of acetyl Co-A derived from long-chain fatty acid β-oxidation into the mitochondria is facilitated by the mitoNEET ligand PNU-91325, which increases glucose-derived long chain fatty acid synthesis and breakdown via β-Oxidation and anaplerosis in the mitochondaria.
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Medicinal Chemistry, Metabolic Profiling and Drug Target Discovery: A Role for Metabolic Profiling in Reverse Pharmacology and Chemical Genetics
TL;DR: An overview of the rapidly developing field of "metabolic profiling" is presented, which includes the use of NMR in gene function analysis, GC-based studies on the identification of metabolic pathways affected by PPAR-gamma agonists, applications of Fourier-transform MS and theUse of stable isotope-based metabolic profiling (SIDMAP) to investigate metabolic adaptive changes induced by effective anticancer agents.