George H. Caughey

TL;DR: Regulation of angiogenesis during squamous carcinogenesis is biphasic: in hyperplasias, dysplasia, and invading cancer fronts, inflammatory mast cells are conscripted to reorganize stromal architecture and hyperactivate angiynthesis; within the cancer core, upregulation ofAngiogenesis factors in tumor cells apparently renders them self-sufficient at sustaining neovascularization.

TL;DR: It is found that a large proportion of primary spinal afferent neurons also contain the proinflammatory neuropeptides calcitonin gene-related peptide and substance P, which mediate inflammatory edema induced by agonists of proteinase-activated receptor 2.

TL;DR: Tryptases and chymases are the major proteins stored and secreted by mast cells and play multiple roles in host defense, and any accounting of benefit versus harm is necessarily context specific.

TL;DR: It is reported here that tryptase, a trypsin-like serine proteinase of mast cell secretory granules, is a potent mitogen for fibroblasts in vitro and may provide a molecular link between mast cell activation and fibrosis.

TL;DR: A potential role for neutrophil proteases in the pathogenesis of increased and abnormal submucosal gland secretions in diseases associated with inflammation and neutrophils infiltration of the airways is suggested.