Showing papers by "George L. Mutter published in 1987"

Distinct developmental patterns of c-mos protooncogene expression in female and male mouse germ cells.

Abstract: The protooncogene c-mos is expressed in murine reproductive tissues, producing transcripts of 17 and 14 kilobases in testis and ovary, respectively In situ hybridization analysis of c-mos expression in histological sections of mouse ovaries revealed that oocytes are the predominant if not exclusive source of c-mos transcripts c-mos transcripts accumulate in growing oocytes, increasing 40- to 90-fold during oocyte and follicular development c-mos transcripts were also detected in male germ cells and are most abundant after the cells have entered the haploid stage of spermatogenesis This developmentally regulated pattern of c-mos expression in oocytes and spermatogenic cells suggests that the c-mos gene product may have a function in normal germ-cell differentiation or early embryogenesis

Bleomycin-associated pulmonary fibrosis: rapidly fatal progression without chest radiotherapy.

Abstract: Two patients with carcinoma of the tonsil were treated with bleomycin (396 and 224 units, respectively) but not with radiotherapy. Respiratory insufficiency led to death 45 and 52 days, respectively, after onset of therapy. Chest radiographs before bleomycin therapy revealed no evidence for lung disease. Postmortem examinations showed severe interstitial and intraalveolar pulmonary fibrosis. Comparably rapid progression from radiographically normal pulmonary parenchyma to fatal fibrosis has been documented previously only in patients with thoracic neoplasia as well as, in all but one instance, either prior or concurrent chest radiotherapy. These two cases indicate that chest radiotherapy is not a necessary cofactor for the development of rapidly progressive, fatal, diffuse interstitial pulmonary fibrosis after bleomycin therapy.