George O. Angheloiu

TL;DR: In situ proteomic evidence is provided consistent with the "iron hypothesis," which proposes an association between excessive iron storage and a high risk of CAD, and suggests that increased expression of the ferritin light chain may contribute to pathogenesis of CAD by modulating oxidation of lipids within the vessel wall through the generation of reactive oxygen species.

TL;DR: Large-scale gene expression analysis of approximately 12,000 human genes in nine severely atherosclerotic and six nonatherosclerosis human coronary arteries identified 56 genes whose expression is associated with CAD, and 49 of them may represent new genes linked to CAD.

TL;DR: Evidence is presented that multimodal spectroscopy (MMS) provides depth-sensitive and complementary morphological information about plaque composition and a prospective in vivo study will be conducted to validate these findings.

TL;DR: In this paper, a multimodal spectroscopy method that combines diffuse reflectance spectroscopy (DRS), intrinsic fluorescence spectro-spectroscopy IFS, and Raman Spectroscopy RS was proposed to detect plaque vulnerability.

TL;DR: It is shown that TES is involved in endothelial cell (EC) functions relevant to atherosclerosis, and the possibility that reduced TES expression increases susceptibility to the development of CAD is raised.