G
George Semango
Researcher at National Institute of Advanced Industrial Science and Technology
Publications - 13
Citations - 154
George Semango is an academic researcher from National Institute of Advanced Industrial Science and Technology. The author has contributed to research in topics: Atopic dermatitis & Medicine. The author has an hindex of 5, co-authored 11 publications receiving 99 citations. Previous affiliations of George Semango include Kilimanjaro Christian Medical College & Nelson Mandela African Institute of Science and Technology.
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Journal ArticleDOI
Alternatively spliced isoforms of IL-32 differentially influence cell death pathways in cancer cell lines
Bas Heinhuis,Theo S. Plantinga,George Semango,Benno Küsters,Mihai G. Netea,Charles A. Dinarello,Jan W. A. Smit,Romana T. Netea-Maier,Leo A. B. Joosten +8 more
TL;DR: Modulation of IL-32 alternative splicing could represent a novel strategy for the treatment of malignancies, in particular thyroid cancer.
Journal ArticleDOI
A promoter polymorphism in human interleukin-32 modulates its expression and influences the risk and the outcome of epithelial cell–derived thyroid carcinoma
Theo S. Plantinga,Irene Costantini,Bas Heinhuis,Angelique Huijbers,George Semango,Benno Küsters,Benno Küsters,Mihai G. Netea,Ad R. M. M. Hermus,Jan W. A. Smit,Charles A. Dinarello,Leo A. B. Joosten,Romana T. Netea-Maier +12 more
TL;DR: Individuals bearing genetic variants of IL32 that lead to an increased IL-32γ gene expression and higher production of proinflammatory cytokines have higher risk for developing epithelial cell-derived thyroid carcinoma (TC) and require higher dosages of RAI to achieve successful tumor remission.
Journal ArticleDOI
Prevalence and associated risk factors for Kaposi's sarcoma among HIV-positive patients in a referral hospital in Northern Tanzania: a retrospective hospital-based study.
George Semango,Renard M. Charles,Consolata I. Swai,Alex Mremi,Patrick Amsi,Tolbert Sonda,Elichilia R Shao,Daudi R. Mavura,Leo A. B. Joosten,Elingarami Sauli,Mramba Nyindo +10 more
TL;DR: Kaposi’s sarcoma remains a common malignant vascular tumor commonly associated with HIV/AIDS in Tanzania, and the need for continued efforts to combat HIV, as well as associated diseases such as KS is highlighted.
Journal ArticleDOI
The Sero-epidemiology of Neospora caninum in Cattle in Northern Tanzania.
George Semango,Clare M. Hamilton,Katharina Kreppel,Frank Katzer,Tito Kibona,Felix Lankester,Kathryn J. Allan,Kate M. Thomas,John R. Claxton,E.A. Innes,Emmanuel S. Swai,Joram Buza,Sarah Cleaveland,William A. de Glanville +13 more
TL;DR: The findings suggest N. caninum is likely to be an important cause of abortion in cattle in Tanzania and management practices, such as restricted grazing, are likely to reduce the risk of infection and suggest contamination of communal grazing areas may be important for transmission.
Journal ArticleDOI
Immune and barrier characterization of atopic dermatitis skin phenotype in Tanzanian patients.
Claudia C.V. Lang,Claudia C.V. Lang,Yael Renert-Yuval,Yael Renert-Yuval,Ester Del Duca,Ana B. Pavel,Ana B. Pavel,Jianni Wu,Ning Zhang,Celina Dubin,Ashley Obi,Mashkura Chowdhoury,Madeline Kim,Yeriel Estrada,James G. Krueger,Hashim Kaderbhai,George Semango,Peter Schmid-Grendelmeier,Marie-Charlotte Brüggen,John E. Masenga,Emma Guttman-Yassky +20 more
TL;DR: Tanzanian patients with atopic dermatitis (AD) showed robust up-regulations of multiple key mediators of both T helper 2 (TH2) (interleukin 13 [IL-13], IL-10, IL-4R, CCL13, CCL17,CCL18, CLC26) and TH22 (IL22, S100As) pathways.