G
Gerald P. Donovan
Researcher at Amgen
Publications - 18
Citations - 1106
Gerald P. Donovan is an academic researcher from Amgen. The author has contributed to research in topics: Epitope & Antigen. The author has an hindex of 11, co-authored 18 publications receiving 1053 citations. Previous affiliations of Gerald P. Donovan include Memorial Sloan Kettering Cancer Center.
Papers
More filters
Journal ArticleDOI
L-SIGN (CD 209L) is a liver-specific capture receptor for hepatitis C virus.
Jason P. Gardner,Robert J. Durso,Robert R. Arrigale,Gerald P. Donovan,Paul J. Maddon,Tatjana Dragic,William C. Olson +6 more
TL;DR: L-SIGN represents a liver-specific receptor for HCV, and L-SIGN and DC-SIGN may play important roles in HCV infection and immunity.
Journal ArticleDOI
The homodimer of prostate-specific membrane antigen is a functional target for cancer therapy
Norbert Schulke,Olga Varlamova,Gerald P. Donovan,Dangshe Ma,Jason P. Gardner,Donna M. Morrissey,Robert R. Arrigale,Cenchen Zhan,Amy J. Chodera,Kenneth G. Surowitz,Paul J. Maddon,Warren D. W. Heston,William C. Olson +12 more
TL;DR: It is reported that PSMA is expressed on tumor cells as a noncovalent homodimer, and a truncated PSMA protein, lacking transmembrane and cytoplasmic domains, also formed homodimers, indicating that the extracellular domain is sufficient for dimerization.
Journal ArticleDOI
Potent antitumor activity of an auristatin-conjugated, fully human monoclonal antibody to prostate-specific membrane antigen.
Dangshe Ma,Christine E. Hopf,Andrew D. Malewicz,Gerald P. Donovan,Peter D. Senter,William Goeckeler,Paul J. Maddon,William C. Olson +7 more
TL;DR: The PSMA ADC significantly improved median survival 9-fold relative to vehicle or isotype-matched ADC and support development of PSMA antibody-auristatin conjugates for therapy of prostate cancer.
Journal ArticleDOI
Protection Against Clostridium difficile Infection With Broadly Neutralizing Antitoxin Monoclonal Antibodies
Andre Marozsan,Dangshe Ma,Kirsten A. Nagashima,Brian Kennedy,Yun Kenneth Kang,Robert R. Arrigale,Gerald P. Donovan,Wells W. Magargal,Paul J. Maddon,William C. Olson +9 more
TL;DR: These humanized mAbs provide insight into C. difficile intoxication and hold promise as potential nonantibiotic agents for improving clinical management of CDI.
Journal ArticleDOI
Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1.
Yun Kenneth Kang,Sofija Andjelic,James M. Binley,Emma T. Crooks,Michael Franti,Sai Prasad N. Iyer,Gerald P. Donovan,Antu K. Dey,Ping Zhu,Kenneth H. Roux,Robert J. Durso,Thomas F Parsons,Paul J. Maddon,John P. Moore,William C. Olson +14 more
TL;DR: SOSIP gp140 trimers represent a soluble, stabilized, proteolytically cleaved form of the HIV-1 envelope (Env) glycoproteins and have been shown to be superior at eliciting neutralizing antibodies to homologous virus as well as neutralization-sensitive subtype B and C viruses.