Structural and immunogenicity studies of a cleaved, stabilized envelope trimer derived from subtype A HIV-1.
Yun Kenneth Kang,Sofija Andjelic,James M. Binley,Emma T. Crooks,Michael Franti,Sai Prasad N. Iyer,Gerald P. Donovan,Antu K. Dey,Ping Zhu,Kenneth H. Roux,Robert J. Durso,Thomas F Parsons,Paul J. Maddon,John P. Moore,William C. Olson +14 more
Reads0
Chats0
TLDR
SOSIP gp140 trimers represent a soluble, stabilized, proteolytically cleaved form of the HIV-1 envelope (Env) glycoproteins and have been shown to be superior at eliciting neutralizing antibodies to homologous virus as well as neutralization-sensitive subtype B and C viruses.About:
This article is published in Vaccine.The article was published on 2009-08-13 and is currently open access. It has received 69 citations till now.read more
Citations
More filters
Journal ArticleDOI
HIV-1 neutralizing antibodies induced by native-like envelope trimers
Rogier W. Sanders,Rogier W. Sanders,Marit J. van Gils,Ronald Derking,Devin Sok,Devin Sok,Thomas J. Ketas,Judith A. Burger,Gabriel Ozorowski,Gabriel Ozorowski,Albert Cupo,Cassandra A. Simonich,Leslie Goo,Heather Arendt,Helen J. Kim,Helen J. Kim,Jeong Hyun Lee,Jeong Hyun Lee,Pavel Pugach,Melissa Williams,Gargi Debnath,Brian Moldt,Brian Moldt,Mariëlle J. van Breemen,Gözde Isik,Max Medina-Ramírez,Jaap Willem Back,Wayne C. Koff,Jean-Philippe Julien,Jean-Philippe Julien,Eva G. Rakasz,Michael S. Seaman,Michael S. Seaman,Miklos Guttman,Kelly K. Lee,Per Johan Klasse,Celia C. LaBranche,William R. Schief,Ian A. Wilson,Julie Overbaugh,Dennis R. Burton,Andrew B. Ward,Andrew B. Ward,David C. Montefiori,Hansi J. Dean,John P. Moore +45 more
TL;DR: A major goal of HIV-1 vaccine development is to identify immunogens capable of inducing protective titers of broadly neutralizing antibodies (bNAbs) against circulating, neutralization-resistant (tier 2) viruses, and soluble, recombinant trimers based on the BG505 clade A and B41 clade B tier 2 viruses are engineered.
Journal ArticleDOI
A Blueprint for HIV Vaccine Discovery
Dennis R. Burton,Rafi Ahmed,Rafi Ahmed,Dan H. Barouch,Dan H. Barouch,Dan H. Barouch,Salvatore T. Butera,Shane Crotty,Shane Crotty,Adam Godzik,Adam Godzik,Daniel Kaufmann,Daniel Kaufmann,M. Juliana McElrath,M. Juliana McElrath,Michel C. Nussenzweig,Michel C. Nussenzweig,Michel C. Nussenzweig,Bali Pulendran,Bali Pulendran,Christopher N. Scanlan,Christopher N. Scanlan,William R. Schief,Guido Silvestri,Guido Silvestri,Guido Silvestri,Hendrik Streeck,Bruce D. Walker,Bruce D. Walker,Laura M. Walker,Andrew B. Ward,Ian A. Wilson,Richard T. Wyatt +32 more
TL;DR: It is proposed that studies focused on how best to provide T cell help to B cells that produce bnAbs are crucial for optimal immunization strategies, and the synthesis of rational immunogen design and immunization Strategies offers great promise for advancing toward an HIV vaccine.
Journal ArticleDOI
Rational antibody-based HIV-1 vaccine design: current approaches and future directions.
TL;DR: Recent structural studies of HIV-1 Env proteins, generation of novel bNAbs, maturation of technologies for the isolation of further antibodies, insights into the requirements for antibody-mediated protection, and novel vaccination approaches are providing grounds for renewed optimism.
Journal ArticleDOI
Native‐like Env trimers as a platform for HIV‐1 vaccine design
TL;DR: Native‐like trimers are a platform for structure‐ and immunology‐based design improvements that could eventually yield immunogens of practical value for solving the long‐standing HIV‐1 vaccine problem.
Journal ArticleDOI
Trimeric HIV-1 glycoprotein gp140 immunogens and native HIV-1 envelope glycoproteins display the same closed and open quaternary molecular architectures
Audray K. Harris,Mario J. Borgnia,Dan Shi,Alberto Bartesaghi,Haifeng He,Robert Pejchal,Yun Kenneth Kang,Rafael S. Depetris,Andre Marozsan,Rogier W. Sanders,Per Johan Klasse,Jacqueline L. S. Milne,Ian A. Wilson,William C. Olson,John P. Moore,Sriram Subramaniam +15 more
TL;DR: It is demonstrated that soluble gp140 trimers can be designed to mimic the quaternary structural transitions displayed by native trimeric Env on the surface of intact HIV-1 virions.
References
More filters
Journal ArticleDOI
Spider and web : processing and visualization of images in 3d electron microscopy and related fields
Joachim Frank,Michael Radermacher,Michael Radermacher,Pawel A. Penczek,Jun Zhu,Jun Zhu,Yanhong Li,Mahieddine Ladjadj,Ardean Leith +8 more
TL;DR: Novel features are a suite of operations relating to the determination, modeling, and correction of the contrast transfer function and the availability of the entire documentation in hypertext format.
Journal ArticleDOI
Identification and characterization of transmitted and early founder virus envelopes in primary HIV-1 infection
Brandon F. Keele,Elena E. Giorgi,Elena E. Giorgi,Jesus F. Salazar-Gonzalez,Julie M. Decker,Kimmy T. Pham,Maria G. Salazar,Chuanxi Sun,Truman Grayson,Shuyi Wang,Hui Li,Xiping Wei,Chunlai Jiang,Jennifer L. Kirchherr,Feng Gao,Jeffery A. Anderson,Li Hua Ping,Ronald Swanstrom,Georgia D. Tomaras,William A. Blattner,Paul A. Goepfert,J. Michael Kilby,Michael S. Saag,Eric Delwart,Michael P. Busch,Myron S. Cohen,David C. Montefiori,Barton F. Haynes,Brian Gaschen,Gayathri Athreya,Ha Y. Lee,Natasha T. Wood,Cathal Seoighe,Alan S. Perelson,Tanmoy Bhattacharya,Tanmoy Bhattacharya,Bette T. Korber,Bette T. Korber,Beatrice H. Hahn,George M. Shaw +39 more
TL;DR: A mathematical model of random viral evolution and phylogenetic tree construction is developed and used to analyze 3,449 complete env sequences derived by single genome amplification from 102 subjects with acute HIV-1 (clade B) infection, suggesting a finite window of potential vulnerability of HIV- 1 to vaccine-elicited immune responses, although phenotypic properties of transmitted Envs pose a formidable defense.
Journal ArticleDOI
Protection of macaques against vaginal transmission of a pathogenic HIV-1/SIV chimeric virus by passive infusion of neutralizing antibodies.
John R. Mascola,Gabriela Stiegler,Thomas C. VanCott,Hermann Katinger,Calvin B. Carpenter,Chris E. Hanson,Holly Beary,Deborah Hayes,Sarah S. Frankel,Deborah L. Birx,Mark G. Lewis +10 more
TL;DR: It is demonstrated that antibodies can affect transmission and subsequent disease course after vaginal SHIV-challenge, and the data begin to define the type of antibody response that could play a role in protection against mucosal transmission of HIV-1.
Journal ArticleDOI
Rapid evolution of the neutralizing antibody response to HIV type 1 infection
TL;DR: Plasma virus continually and rapidly evolved to escape neutralization, indicating that neutralizing antibody exerts a level of selective pressure that has been underappreciated based on earlier, less comprehensive characterizations.
Journal ArticleDOI
Efficient neutralization of primary isolates of HIV-1 by a recombinant human monoclonal antibody
Dennis R. Burton,Jayashree Pyati,Raju Koduri,Stephen J. Sharp,George B. Thornton,Paul W. H. I. Parren,Lynette S. W. Sawyer,R. Michael Hendry,N Dunlop,Peter L. Nara,Michael Lamacchia,Eileen Garratty,E. Richard Stiehm,Yvonne J. Bryson,Yunzhen Cao,John P. Moore,David D. Ho,Carlos F. Barbas +17 more
TL;DR: A recombinant human antibody to envelope glycoprotein gp120 was generated and used to show that primary isolates are not refractory to antibody neutralization, implying the conservation of a structural feature on gp120, which could be important in vaccine design.
Related Papers (5)
Broad and potent neutralizing antibodies from an African donor reveal a new HIV-1 vaccine target.
Laura M. Walker,Sanjay Phogat,Po-Ying Chan-Hui,Denise Wagner,Pham Phung,Julie L. Goss,Terri Wrin,Melissa Simek,Steven P. Fling,Jennifer L. Mitcham,Jennifer Lehrman,Frances Priddy,Ole A. Olsen,Steven Frey,Phillip W. Hammond,Protocol G. Principal Investigators,Stephen M. Kaminsky,Timothy J. Zamb,Matthew Moyle,Wayne C. Koff,Pascal Poignard,Dennis R. Burton,Dennis R. Burton +22 more
Rational Design of Envelope Identifies Broadly Neutralizing Human Monoclonal Antibodies to HIV-1
Xueling Wu,Zhi Yong Yang,Yuxing Li,Carl Magnus Hogerkorp,William R. Schief,Michael S. Seaman,Tongqing Zhou,Stephen D. Schmidt,Lan Wu,Ling Xu,Nancy S. Longo,Krisha McKee,Sijy O'Dell,Mark K. Louder,Diane Wycuff,Yu Feng,Martha Nason,Nicole A. Doria-Rose,Mark Connors,Peter D. Kwong,Mario Roederer,Richard T. Wyatt,Gary J. Nabel,John R. Mascola +23 more
Vaccination with ALVAC and AIDSVAX to Prevent HIV-1 Infection in Thailand
Supachai Rerks-Ngarm,Punnee Pitisuttithum,Sorachai Nitayaphan,Jaranit Kaewkungwal,Joseph Chiu,Robert Paris,Nakorn Premsri,Chawetsan Namwat,Mark de Souza,Elizabeth Adams,Michael Benenson,Sanjay Gurunathan,Jim Tartaglia,John G. McNeil,Donald P. Francis,Donald Stablein,Deborah L. Birx,Supamit Chunsuttiwat,Chirasak Khamboonruang,Prasert Thongcharoen,Merlin L. Robb,Nelson L. Michael,Prayura Kunasol,Jerome H. Kim +23 more
Broad neutralization coverage of HIV by multiple highly potent antibodies
Laura M. Walker,Michael Huber,Michael Huber,Katie J. Doores,Katie J. Doores,Emilia Falkowska,Emilia Falkowska,Robert Pejchal,Jean-Philippe Julien,Sheng-Kai Wang,Alejandra Ramos,Po-Ying Chan-Hui,Matthew Moyle,Jennifer L. Mitcham,Phillip W. Hammond,Ole A. Olsen,Pham Phung,Steven P. Fling,Chi-Huey Wong,Sanjay Phogat,Terri Wrin,Melissa Simek,Protocol G. Principal Investigators,Wayne C. Koff,Ian A. Wilson,Dennis R. Burton,Dennis R. Burton,Pascal Poignard,Pascal Poignard +28 more