G
Gerd Leitinger
Researcher at Medical University of Graz
Publications - 107
Citations - 2329
Gerd Leitinger is an academic researcher from Medical University of Graz. The author has contributed to research in topics: Medicine & Chemistry. The author has an hindex of 23, co-authored 90 publications receiving 1804 citations. Previous affiliations of Gerd Leitinger include University of Graz & Newcastle University.
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Journal ArticleDOI
Development of an Advanced Intestinal in Vitro Triple Culture Permeability Model To Study Transport of Nanoparticles
Christa Schimpel,Birgit Johanna Teubl,Markus Absenger,Claudia Meindl,Eleonore Fröhlich,Gerd Leitinger,Andreas Zimmer,Eva Roblegg +7 more
TL;DR: It can be concluded that goblet cells and M cells strongly impact nanoparticle uptake in the intestine and should thus be integrated in an in vitro permeability model, and will be an efficient tool to study intestinal transcellular uptake of particulate systems.
Journal ArticleDOI
Cellular uptake and toxicity effects of silver nanoparticles in mammalian kidney cells
Mirta Milić,Gerd Leitinger,Ivan Pavičić,Maja Zebić Avdičević,Slaven Dobrović,Walter Goessler,Ivana Vinković Vrček +6 more
TL;DR: A detailed study on the in vitro interactions of citrate‐coated AgNPs with porcine kidney (Pk15) cells is reported, suggesting that a rather high concentration of AgNP is able to induce genotoxicity in Pk15 cells.
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Comparison of two in vitro systems to assess cellular effects of nanoparticles-containing aerosols
Eleonore Fröhlich,Gudrun Bonstingl,Anita Höfler,Claudia Meindl,Gerd Leitinger,Thomas R. Pieber,Eva Roblegg +6 more
TL;DR: A new VITROCELL – Pariboy system was evaluated for testing of aerosolized NPs and polystyrene nanoparticles acted more cytotoxic as aerosols than as suspensions.
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The oral cavity as a biological barrier system: design of an advanced buccal in vitro permeability model.
Birgit Johanna Teubl,Markus Absenger,Eleonore Fröhlich,Gerd Leitinger,Andreas Zimmer,Eva Roblegg +5 more
TL;DR: An advanced buccal in vitro model for studying transport of nanoparticles, taking the mucus layer into account was developed and revealed that porcine mucin is most similar to human natural mucin in chemical structure and morphology.
Journal ArticleDOI
More than cell dust: microparticles isolated from cerebrospinal fluid of brain injured patients are messengers carrying mRNAs, miRNAs, and proteins.
Silke Patz,Christa Trattnig,Gerda Grünbacher,Birgit Ebner,Christian Gülly,Alexandra Novak,Beate Rinner,Gerd Leitinger,Markus Absenger,Oana Alina Tomescu,Gerhard G. Thallinger,Ulrike Fasching,Sonja Maria Wissa,Juan-Jose Archelos-Garcia,Ute Schäfer +14 more
TL;DR: The transfer of genetic material from CSF microparticles to adult neuronal stem cells in vitro and a subsequent microRNA-specific repression of distinct genes are confirmed, marking the first indication of a regulated transport of functional genetic material in human CSF.